en Genetics & Disease Genetics & Disease Original Article Original Article <p style="text-align: justify;">It has been well documented that preeclampsia (PE) has a common etiological background, but little is known about its linkage at the molecular level.Non- coding RNAs are critical posttranscriptional regulators ofgene expression.&nbsp; This study was performed to determine whether PEis associated with alterations in placental non-codingRNAs expression. MicroRNA(miR)-155-5p and long non-coding RNA (<em>lnc</em>)<em>sONE</em> expression, in placentas collected sequentially from 59 patients with PE and 40 normotensive pregnancies were measured using real-time PCR.The relationship between miR-155-5p and <em>lncsONE</em> expressions wasanalyzed statistically. miR-155-5p expression was increased<em>(</em>fold change=1.6, P=0.04<em>)</em>, while<em>lncsONE </em>expression was not significantly changed<em>(</em>fold change=1.1, P=0.68<em>)</em>, in placentas from patients compared with control group.miR-155-5p was upregulated in placentas from patients with PEand may have influenced<em>eNOS</em> expression. These findings indicate that miRNA-155-5p may be involved in PE pathogenesis and could be a potential biomarker for this disease.</p> Preeclampsia, miR-155-5p, long non-coding RNA sONE, real time PCR 22 30 http://ijmcmed.org/browse.php?a_code=A-10-1034-1&slc_lang=en&sid=1 Faezeh Azizi faezehazizi1@gmail.com 10031947532846008650 10031947532846008650 No Department of Medical Genetics, Faculty of Medicine, ShahidBeheshtiUniversity of Medical Sciences,Tehran, Iran. Soraya Saleh Gargari soraya_saleh2000@yahoo.co.uk 10031947532846008651 10031947532846008651 No Feto-Maternal Unit, ShohadayeTajrish Hospital, ShahidBeheshti, University of Medical Sciences, Tehran, Iran. Sedigheh Asadi Shahmirzadi se.shahmirzadi@yahoo.com 10031947532846008652 10031947532846008652 No Feto-Maternal Unit, Mahdiyeh Hospital, ShahidBeheshti, University of Medical Sciences, Tehran, Iran. Fatemeh Dodange fa.dodange@yahoo.com 10031947532846008653 10031947532846008653 No Feto-Maternal Unit, Mahdiyeh Hospital, ShahidBeheshti, University of Medical Sciences, Tehran, Iran. Vahid Amiri vahid.amiri529@gmail.com 10031947532846008654 10031947532846008654 No School of Allied Medical Sciences,ShahidBeheshti, University of Medical Sciences, Tehran, Iran. Reza Mirfakhraie reza_mirfakhraie@yahoo.com 10031947532846008655 10031947532846008655 No Department of Medical Genetics, Faculty of Medicine, ShahidBeheshtiUniversity of Medical Sciences,Tehran, Iran. Mir Davood Omrani Davood_omrani@yahoo.co.uk 10031947532846008656 10031947532846008656 Yes Department of Medical Genetics, Faculty of Medicine, ShahidBeheshtiUniversity of Medical Sciences,Tehran, Iran.