International Journal of Molecular and Cellular Medicine
مجله بین المللی سلولی و مولکولی
Int J Mol Cell Med
Medical Sciences
http://ijmcmed.org
1
admin
2251-9637
2251-9645
10.22088/IJMCM.BUMS
en
jalali
1391
9
1
gregorian
2012
12
1
1
3
online
1
fulltext
en
Hematologic Features of Alpha Thalassemia Carriers
Genetics & Disease
Genetics & Disease
Original Article
Original Article
Alpha thalassemia (α-thal) is relatively common worldwide. Most carriers are defective in either one or two alpha globin genes out of four functional ones, with deletions being more common than point mutations. The hematologic features are very important for the selection of the appropriate molecular tests while determining the genotype. The aim of this study was to compare hematologic features of patients with various types of α globin mutations. Hematological indices including red blood cells (RBC), hemoglobin concentration (Hb), mean cell volume (MCV), mean cell hemoglobin (MCH), Mean corpuscular hemoglobin concentration (MCHC) and percentage of Hemoglobin (HBA1, HBA2 and HBF) of seven-hundred and twenty two patients presenting ten different α-thal genotypes were considered. All patients showed reduced MCV and/or MCH values. Moreover, MCV and MCH were lower in patients with two functional alpha globin genes in comparison to patients with one mutated alpha globin gene (P value<0.001). In conclusion, MCV and MCH values can be helpful for the selection of the appropriate molecular tests to determine the genotype of alpha thalassemia carriers.
Alpha thalassemia, Mean cell volume, Mean cell hemoglobin, Mutation
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http://ijmcmed.org/browse.php?a_code=A-10-24-2&slc_lang=en&sid=1
Haleh
Akhavan-Niaki
halehakhavan@yahoo.com
10031947532846002301
10031947532846002301
Yes
Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.
Reza
Youssefi Kamangari
10031947532846002302
10031947532846002302
No
Genetic Laboratory of Amirkola Children Hospital, Babol University of Medical Sciences, Babol, Iran.
Ali
Banihashemi
10031947532846002303
10031947532846002303
No
- Genetic Laboratory of Amirkola Children Hospital, Babol University of Medical Sciences, Babol, Iran.
Vahid
Kholghi Oskooei
10031947532846002304
10031947532846002304
No
Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.
Mandana
Azizi
10031947532846002305
10031947532846002305
No
Genetic Laboratory of Amirkola Children Hospital, Babol University of Medical Sciences, Babol, Iran.
Ahmad
Tamaddoni
10031947532846002306
10031947532846002306
No
Non-Communicable Pediatric Diseases Research Center, Babol University of Medical Sciences, Babol, Iran.
Sadegh
Sedaghat
10031947532846002307
10031947532846002307
No
Ayatollah Roohani Hospital, Babol University of Medical Sciences, Babol, Iran.
Mohsen
Vakili
10031947532846002308
10031947532846002308
No
Ayatollah Roohani Hospital, Babol University of Medical Sciences, Babol, Iran.
Hassan
Mahmoudi Nesheli
10031947532846002309
10031947532846002309
No
Non-Communicable Pediatric Diseases Research Center, Babol University of Medical Sciences, Babol, Iran.
Soraya
Shabani
10031947532846002310
10031947532846002310
No
Genetic Laboratory of Amirkola Children Hospital, Babol University of Medical Sciences, Babol, Iran.