International Journal of Molecular and Cellular Medicine
مجله بین المللی سلولی و مولکولی
Int J Mol Cell Med
Medical Sciences
http://ijmcmed.org
1
admin
2251-9637
2251-9645
10.22088/IJMCM.BUMS
en
jalali
1395
10
1
gregorian
2017
1
1
6
1
online
1
fulltext
en
Analysis of Two CDKN2B-AS Polymorphisms in Relation to Coronary Artery Disease Patients in North of Iran
Genetics & Disease
Genetics & Disease
Original Article
Original Article
<p style="text-align: justify;">Coronary artery disease (CAD) including myocardial infarction (MI) as its complication, is one of the most common heart diseases worldwide and also in Iran, with extremely elevated mortality. CAD is a multifactorial disorder. Twin and family studies at different loci have demonstrated that genetic factors have an important role in the progression of CAD. Many studies have reported a significant association of <em>CDKN2B-AS</em>, also known as <em>ANRIL</em> which is located within the p15, p16, p14 gene cluster at 9p21 locus, with cardiovascular diseases as well as many other diseases like diabetes and cancers. This study investigated two polymorphisms rs10757274 and rs1333042 of <em>CDKN2B-AS</em> gene at 9p21 locus. 205 subjects, comprising 102 controls and 103 CAD patients were genotyped by TaqMan probe real time PCR technique and haplotypes were examined. This study confirmed the association of rs10757274 variants with CAD in Iranian patients (P= 0.003) but genotype and allele distributions of CAD and control groups showed no significant association for the rs1333042. However, frequency of the [G;G] haplotype of these two SNPs was significantly higher in CAD group (P= 0.0002, Odds Ratio = 3.1, 95% CI = 1.7-5.7). Our finding suggests that [G; G] haplotype of rs10757274 and rs1333042 may be considered as a genetic risk factor for susceptibility to CAD in Iranian patients.</p>
Single nucleotide polymorphism, risk factor, coronary artery disease, CDKN2B-AS, Iranian
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http://ijmcmed.org/browse.php?a_code=A-10-763-1&slc_lang=en&sid=1
Maryam
Mafi Golchin
maryam.mafi@rocketmail.com
10031947532846008635
10031947532846008635
No
Department of Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
Sayyed Mohammad Hossein
Ghaderian
sghaderian@yahoo.co.uk
10031947532846008636
10031947532846008636
Yes
Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Haleh
Akhavan-Niaki
halehakhavan@yahoo.com
10031947532846008637
10031947532846008637
No
Department of Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
Rozita
Jalalian
rozita_jalalian@yahoo.com
10031947532846008638
10031947532846008638
No
Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Laleh
Hedari
khanomeheidari@yahoo.com
10031947532846008639
10031947532846008639
No
Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ali Reza
Salami
asalami@ut.ac.ir
10031947532846008640
10031947532846008640
No
Department of Biotechnology, University of Tehran, Tehran, Iran.