International Journal of Molecular and Cellular Medicine
مجله بین المللی سلولی و مولکولی
Int J Mol Cell Med
Medical Sciences
http://ijmcmed.org
1
admin
2251-9637
2251-9645
10.22088/IJMCM.BUMS
en
jalali
1395
4
1
gregorian
2016
7
1
5
3
online
1
fulltext
en
Utility of Specific IgE to Ara h 2 in Italian Allergic and Tolerant Children Sensitized to Peanut
Biomarkers (diagnosis & treatment)
Biomarkers (diagnosis & treatment)
Original Article
Original Article
<p style="text-align: justify;">Emerging data suggest that measurement of serum IgE to peanut components can be clinically helpful and more accurate than IgE to whole peanut to predict peanut allergy. Not all studies have used prospective samples, multiple components and oral challenges. Currently, there are no data on this topic involving Italian children. 32 patients (23 males; median age 9 years) with reported history for peanut allergy and evidence of peanut sensitization (skin prick test to peanut extract ≥ 3mm) have been analyzed for serum IgE to whole peanut and recombinant allergen components Ara h 1, 2, 3, 8, and 9 with Immuno CAP and completed an open oral food challenge with peanut. 12 (37.5%) children had a positive challenge to peanut and were considered allergic. No differences were seen between the median values of IgE to peanut, Ara h 1, 3, 8 and 9 in allergic and tolerant children to peanut challenge. Noteworthy, 5 of 20 tolerant children had IgE to peanut> 15 kUA/l which is commonly considered a predictive value of peanut allergy. Conversely, a significant difference was seen when comparing the median value of IgE to Ara h 2 in the two groups: 0.75 kUA/l (IQR: 0.22-4.34 kUA/l) in allergic children versus 0.1 kUA/l (IQR: 0.1-0.12 kUA/l) in tolerant ones (P< 0.001). IgE levels to Ara h 2 are significantly higher in children that react to oral peanut challenge. Our findings in Italian children have been in line with recent reports in various populations of Northern Europe, the US and Australia and add confirmatory evidence that analysis of IgE to Ara h 2 could reduce the need for peanut challenge in suspected allergic patients.</p>
Allergy, Ara h 2, peanut, specific Ig E
160
166
http://ijmcmed.org/browse.php?a_code=A-10-762-1&slc_lang=en&sid=1
Pasquale
Comberiati
10031947532846007745
10031947532846007745
No
Department of Scienze Chirurgiche, Odontostomatologiche e Materno-infantili, section of Paediatrics, University of Verona, Italy.
Laura
Colavita
lauracol85@gmail.com
10031947532846007746
10031947532846007746
Yes
Department of Paediatrics, Unit of Genetics and Pediatric Immunology, University Hospital of Messina, Italy.
Federica
Minniti
10031947532846007747
10031947532846007747
No
Department of Scienze Chirurgiche, Odontostomatologiche e Materno-infantili, section of Paediatrics, University of Verona, Italy.
Paiola
Giulia
10031947532846007748
10031947532846007748
No
Department of Scienze Chirurgiche, Odontostomatologiche e Materno-infantili, section of Paediatrics, University of Verona, Italy.
Carlo
Capristo
10031947532846007749
10031947532846007749
No
Department of Paediatrics, Faculty of Medicine, Second University of Naples, Naples, Italy.
Cristoforo
Incorvaia
10031947532846007750
10031947532846007750
No
Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, Italy.
Giampietro Peroni
Diego
10031947532846007751
10031947532846007751
No
Department of Clinical and Experimental Medicine, section of Paediatrics, University of Pisa, Italy.