en Genetics & Disease Genetics & Disease Case Report Case Report <p dir="ltr">We present 2 cases of likely rare event. In case 1, 3^rd degree consanguineous marriage revealed inv(6) with same break points in parents who were found to be phenotypically normal. The same inv(6) being inherited in progeny but presented with low AMH (anti Mullerian hormone) and high level of FSH (follicular stimulating hormone) leading to polycystic ovarian syndrome/premature ovarian failure. In case 2, a couple was presented with 2^nd degree consanguineous marriage and referred for 2 recurrent/ missed abortions. The amounts of shared genes are suggestive of more lethal genetic outcomes and inferred endogamy is a major driver to reproductive fiascoes, the ancestries of which are deeply tied at the meiotic level.</p> Consanguinity, endogamy, inversion, familial translocations, conventional cytogenetics 57 64 http://ijmcmed.org/browse.php?a_code=A-10-642-1&slc_lang=en&sid=1 Debarshi Sanyal jupiterdev@gmail.com 10031947532846009411 10031947532846009411 Yes Lilac Insight Pvt Ltd, Ambience Court, 19th Floor, Unit 1901 & 1902, Sec-19 Vashi, Navi Mumbai 400705 Maharashtra, India. Vidya Bhairi vbhairi@gmail.com 10031947532846009412 10031947532846009412 No Lilac Insight Pvt Ltd, Ambience Court, 19th Floor, Unit 1901 & 1902, Sec-19 Vashi, Navi Mumbai 400705 Maharashtra, India. Jayarama S Kadandale jayaram@ibab.ac.in 10031947532846009413 10031947532846009413 No Centre For Human Genetics, Biotech Park, Electronic City, Phase- I, Bangalore-560100, Karnataka, India.