International Journal of Molecular and Cellular Medicine
مجله بین المللی سلولی و مولکولی
Int J Mol Cell Med
Medical Sciences
http://ijmcmed.org
1
admin
2251-9637
2251-9645
10.22088/IJMCM.BUMS
en
jalali
1394
11
1
gregorian
2016
2
1
5
1
online
1
fulltext
en
Zinc Finger 259 Gene Polymorphism rs964184 is Associated with Serum Triglyceride Levels and Metabolic Syndrome
Genetics & Disease
Genetics & Disease
Original Article
Original Article
<p dir="ltr" style="text-align: justify;">Metabolic syndrome (MetS) is characterized by a cluster of cardiovascular risk factors that include: abdominal obesity, dyslipidaemia, hypertension, insulin resistance and impaired glucose tolerance. Recent genome wide association studies have identified several susceptibility regions involved in lipid metabolism that are also associated with MetS. We have explored the association of 9 genetic polymorphisms involved in lipid metabolism and hypertension, including: <em>MTHFR</em> C677T, <em>SELE</em> L554F,<em> FGB </em>- 455G>A,<em> GNB3</em> C825T<em>, ZNF259 C>G, PSRC-1 </em>A>G<em>, CETP </em>I405V<em>, LPL </em>S447X and<em> LPA</em> C>T in 97 subjects with mets and 96 individuals without MetS who were recruited randomly from Mashhad stroke and heart atherosclerotic disorder (MASHAD) study using a stratified cluster random sampling technique. Anthropometric parameters and biochemical measurements were determined in all the subjects. Genotyping was carried out followed by univariate and multivariate analyses. The subjects with MetS had a higher triglyceride and lower HDL- C. CG+ GG genotypes of <em>ZNF259 </em>polymorphism (rs964184 C>G) and TT+CT genotypes of <em>MTHFR</em> C677T (rs1801133) were associated with MetS, and individuals carrying the G allele for <em>ZNF259 </em>or the T allele for <em>MTHFR</em> polymorphisms were associated with MetS (e.g, odds ratio (OR) for CG+GG genotypes vs. CC wild type: 2.52, CI=1.33-4.77; P=0.005). However, after multiple comparison adsustments, this relationship remained significant only for CG+ GG genotypes of <em>ZNF259 </em>polymorphism. Moreover, the <em>ZNF259</em> CG+ GG genotypes were associated with increased serum concentrations of triglycerides and LDL-C, compared to the wild type. These data support the necessity of further studies in larger multicenter settings.</p>
Metabolic syndrome, gene polymorphisms, lipid pathway
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18
http://ijmcmed.org/browse.php?a_code=A-10-634-4&slc_lang=en&sid=1
Seyed Reza
Mirhafez
Mirhafezr@yahoo.com
10031947532846009369
10031947532846009369
No
Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Amir
Avan
amir_avan@yahoo.com
10031947532846009370
10031947532846009370
No
Department of Modern Science and Technologies; and Biochemistry of Nutrition Research Center; School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Alireza
Pasdar
Pasdara@mums.ac.ir
10031947532846009371
10031947532846009371
No
Division of Applied Medicine, Medical School, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK.
Sara
Khatamianfar
monarch_371@yahoo.com
10031947532846009372
10031947532846009372
No
Department of Modern Science and Technologies; and Biochemistry of Nutrition Research Center; School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Leila
Hosseinzadeh
monarch_367@yahoo.com
10031947532846009373
10031947532846009373
No
Department of Modern Science and Technologies; and Biochemistry of Nutrition Research Center; School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Shiva
Ganjali
GanjaliSh931@mums.ac.ir
10031947532846009374
10031947532846009374
No
Department of Modern Science and Technologies; and Biochemistry of Nutrition Research Center; School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Ali
Movahedi
10031947532846009375
10031947532846009375
No
Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Maryam
Pirhoushiaran
10031947532846009376
10031947532846009376
No
VU University Medical Center, Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
Valentina
Gómez Mellado
10031947532846009377
10031947532846009377
No
VU University Medical Center, Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
Domenico
Rosace
10031947532846009378
10031947532846009378
No
University of Bologna, Bologna, Italy.
Anne
van Krieken
10031947532846009379
10031947532846009379
No
Peter MacCallum Centre, St Andrew's Place, Melbourne, Australia.
Mahdi
Nohtani
10031947532846009380
10031947532846009380
No
Department of Modern Science and Technologies; and Biochemistry of Nutrition Research Center; School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Gordon
A. Ferns
10031947532846009381
10031947532846009381
No
Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK.
Majid
Ghayour-Mobarhan
10031947532846009382
10031947532846009382
Yes
Department of Modern Science and Technologies; and Biochemistry of Nutrition Research Center; School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.