en Histopathology Histopathology Original Article Original Article <p style="text-align: left;">Odontogenic tumors constitute a group of heterogeneous lesions of benign and malignant neoplasms with variable aggressiveness. Ameloblastomas are a group of benign but locally invasive neoplasms that occur in the jaws and are derived from epithelial elements of the tooth-forming apparatus. We previously described orosomucoid-1 protein expression in odontogenic myxomas. However, whether orosomucoid-1 is expressed in other odontogenic tumors remains unknown. Since orosomucoid-1 belongs to a group of acute-phase proteins and has many functions in health and disease, we identified and analyzed orosomucoid-1 expression in ameloblastoma variants and ameloblastic carcinoma using western blot and immunohistochemical techniques. Thirty cases of ameloblastoma were analyzed for orsomucoid-1; five specimens were fresh for western blot study (four benign ameloblastomas and one ameloblastic carcinoma), and 25 cases of benign ameloblastoma for immunohistochemical assays. Orosomucoid-1 was widely expressed in each tumor variant analyzed in this study, and differential orosomucoid-1 expression was observed between benign and malignant tumor. Orosomucoid-1 may play an important role in the behavior of ameloblastomas and influence the biology and development of the variants of this tumor.</p> Orosomucoid-1, ameloblastoma, ameloblastic carcinoma, odontogenic tumors 49 56 http://ijmcmed.org/browse.php?a_code=A-10-626-1&slc_lang=en&sid=1 Alejandro García-Muñoz alexandro_06uam@yahoo.com.mx 10031947532846009403 10031947532846009403 No Laboratorio de Investigación en Odontología, ALMARAZ/UBIMED, FES Iztacala, UNAM. State of Mexico, Mexico. Ronell Bologna-Molina ronellbologna@hotmail.com 10031947532846009404 10031947532846009404 No Molecular Pathology, Universidad de la República (UDELAR), Montevideo, Uruguay. Mario A. Rodríguez marodri@cinvestav.mx 10031947532846009405 10031947532846009405 No Department of Infectomics and Molecular Pathogenesis, CINVESTAV-IPN, México, D.F, México. Rodrigo Liceaga-Reyes r_liceaga@hotmail.com 10031947532846009406 10031947532846009406 No Maxillofacial Surgery Department. Hospital Juárez de México, México D.F, México. Jose Eduardo Farfán-Morales farfanedu@yahoo.com.mx 10031947532846009407 10031947532846009407 No Instituto Nacional de Pediatría, México D.F, México. Saray Aranda-Romo aran_sa77@hotmail.com 10031947532846009408 10031947532846009408 No Biochemistry, Microbiology and Pathology Laboratory, Faculty of Stomatology, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico. Nelly Molina-Frechero nmolinaf@hotmail.com 10031947532846009409 10031947532846009409 No Health Care Department, Universidad Autónoma Metropolitana, Xochimilco, UAM, México City, Mexico. Rogelio González-González rogegg@hotmail.com 10031947532846009410 10031947532846009410 Yes Department Research, School of Dentistry, Universidad Juárez del Estado de Durango, México.