International Journal of Molecular and Cellular Medicine
مجله بین المللی سلولی و مولکولی
Int J Mol Cell Med
Medical Sciences
http://ijmcmed.org
1
admin
2251-9637
2251-9645
10.22088/IJMCM.BUMS
en
jalali
1394
11
1
gregorian
2016
2
1
5
1
online
1
fulltext
en
Orosomucoid-1 Expression in Ameloblastoma Variants
Histopathology
Histopathology
Original Article
Original Article
<p style="text-align: left;">Odontogenic tumors constitute a group of heterogeneous lesions of benign and malignant neoplasms with variable aggressiveness. Ameloblastomas are a group of benign but locally invasive neoplasms that occur in the jaws and are derived from epithelial elements of the tooth-forming apparatus. We previously described orosomucoid-1 protein expression in odontogenic myxomas. However, whether orosomucoid-1 is expressed in other odontogenic tumors remains unknown. Since orosomucoid-1 belongs to a group of acute-phase proteins and has many functions in health and disease, we identified and analyzed orosomucoid-1 expression in ameloblastoma variants and ameloblastic carcinoma using western blot and immunohistochemical techniques. Thirty cases of ameloblastoma were analyzed for orsomucoid-1; five specimens were fresh for western blot study (four benign ameloblastomas and one ameloblastic carcinoma), and 25 cases of benign ameloblastoma for immunohistochemical assays. Orosomucoid-1 was widely expressed in each tumor variant analyzed in this study, and differential orosomucoid-1 expression was observed between benign and malignant tumor. Orosomucoid-1 may play an important role in the behavior of ameloblastomas and influence the biology and development of the variants of this tumor.</p>
Orosomucoid-1, ameloblastoma, ameloblastic carcinoma, odontogenic tumors
49
56
http://ijmcmed.org/browse.php?a_code=A-10-626-1&slc_lang=en&sid=1
Alejandro
García-Muñoz
alexandro_06uam@yahoo.com.mx
10031947532846009403
10031947532846009403
No
Laboratorio de Investigación en Odontología, ALMARAZ/UBIMED, FES Iztacala, UNAM. State of Mexico, Mexico.
Ronell
Bologna-Molina
ronellbologna@hotmail.com
10031947532846009404
10031947532846009404
No
Molecular Pathology, Universidad de la República (UDELAR), Montevideo, Uruguay.
Mario A.
Rodríguez
marodri@cinvestav.mx
10031947532846009405
10031947532846009405
No
Department of Infectomics and Molecular Pathogenesis, CINVESTAV-IPN, México, D.F, México.
Rodrigo
Liceaga-Reyes
r_liceaga@hotmail.com
10031947532846009406
10031947532846009406
No
Maxillofacial Surgery Department. Hospital Juárez de México, México D.F, México.
Jose Eduardo
Farfán-Morales
farfanedu@yahoo.com.mx
10031947532846009407
10031947532846009407
No
Instituto Nacional de Pediatría, México D.F, México.
Saray
Aranda-Romo
aran_sa77@hotmail.com
10031947532846009408
10031947532846009408
No
Biochemistry, Microbiology and Pathology Laboratory, Faculty of Stomatology, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.
Nelly
Molina-Frechero
nmolinaf@hotmail.com
10031947532846009409
10031947532846009409
No
Health Care Department, Universidad Autónoma Metropolitana, Xochimilco, UAM, México City, Mexico.
Rogelio
González-González
rogegg@hotmail.com
10031947532846009410
10031947532846009410
Yes
Department Research, School of Dentistry, Universidad Juárez del Estado de Durango, México.