en Genomics & Proteomics and Medical Biotechnology Genomics & Proteomics and Medical Biotechnology Review Review <p style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Tahoma;"><span style="line-height:14.0pt"><span lang="EN-ID">Fat build-up can lead to inflammation, which in turn exacerbates health conditions and intensifies complications associated with obesity. This is also related to obesity related gene factors, the FTO gene, which is thought to increase visceral fat. This review investigates the relationship between FTO gene polymorphisms rs9939609 and rs1421085 and visceral fat accumulation.<b> </b>A systematic review was carried out through searches in PubMed, ScienceDirect, and Cochrane databases, from the index date from 2010 to October 2024. Studies with case control, cohort, and cross-sectional designs that discussed the relationship between FTO gene polymorphisms rs9939609 and rs1421085 and increased risk of visceral fat in obese patients were included in this study. This study included 19.732 samples from 11 cohort, case-control, and cross-sectional studies. Five studies revealed that the A allele of rs9939609 and the T allele of rs1421085 were significantly associated with increased visceral fat levels. Findings on the involvement of FTO gene polymorphisms rs9939609 and rs1421085 in visceral fat risk remain inconclusive and warrant further investigation. Therefore, we as researchers support further research that includes the role of this gene in visceral fat using analysis so that it can confirm more precise results in statistics.</span></span></span></span></p> obesity, fat mass, obesity related gene, FTO polymorphism, rs9939609, rs1421085, visceral fat 1250 1260 http://ijmcmed.org/browse.php?a_code=A-10-8291-1&slc_lang=en&sid=1 Agustinus I Wayan Harimawan agustinusharimawan@unud.ac.id 100319475328460037138 0009-0001-7452-753X Yes Department of Clinical Nutrition, Ngoerah Hospital/Faculty of Medicine, Udayana University, Denpasar, Indonesia Desak Made Wihandani dmwihandani@yahoo.co.id 100319475328460037139 100319475328460037139 No Department of Biochemistry, Faculty of Medicine, Udayana University, Denpasar, Indonesia Ni Wayan Jayanti Pradnyandari pradnyajayanti@gmail.com 100319475328460037140 0009-0002-7277-8068 No Department of Clinical Nutrition, Ngoerah Hospital/Faculty of Medicine, Udayana University, Denpasar, Indonesia