en Infectious disease (Molecular and Cellular aspects) Infectious disease (Molecular and Cellular aspects) Original Article Original Article Single-nucleotide polymorphisms (SNPs) in miRNAsmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. Our study aimed to evaluate the possible association between miRNA-146a rs2910164 and miRNA-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (PTB) in a sample of Iranian population. This case- control study was performed on 202 PTB patients and 204 healthy individuals. Genotyping was performed using tetra amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR). The results indicated that neither miRNA-499 rs3746444 nor miRNA-146a rs2910164 are associated with the risk of PTB in a sample of Iranian population. Larger studies with different ethnicities are required to validate our findings. Tuberculosis, microRNA, miRNA-146a, miRNA-499, polymorphism 40 45 http://ijmcmed.org/browse.php?a_code=A-10-296-1&slc_lang=en&sid=1 Mohammad Naderi naderi597@gmail.com 10031947532846004486 10031947532846004486 No Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Mohammad Hashemi mhd.hashemi@gmail.com 10031947532846004487 10031947532846004487 Yes Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Parisa Khorgami parisakhorgami@yahoo.com 10031947532846004488 10031947532846004488 No Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Maliheh Koshki malihehkoshki@yahoo.com 10031947532846004489 10031947532846004489 No Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Mahboubeh Ebrahimi ebrahimi.m22@gmail.com 10031947532846004490 10031947532846004490 No Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Shadi Amininia shadi_am65@yahoo.com 10031947532846004491 10031947532846004491 No Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Batool Sharifi-Mood batoolsharifimood@yahoo.com 10031947532846004492 10031947532846004492 No Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Mosen Taheri amirt112@yahoo.com 10031947532846004493 10031947532846004493 No Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.