en Cancer Cancer Review Review <p><span style="font-size:12px;"><span style="font-family:Tahoma;"><span style="line-height:14.0pt"><span style="color:#231f20">Colorectal cancer (CRC) is a popular type of cancer, characterized by high mortality and a notable impression on the well-being of individuals. The success of adoptive chimeric antigen receptor T (CAR-T) cell therapy in treating hematological malignancies has been remarkable in recent years; however, its application in solid tumors like CRC has many challenges. </span></span><br> <span style="line-height:14.0pt"><span style="color:#231f20">These obstacles encompass the immunosuppressive microenvironment of the tumor, the insufficient targeting of CAR-T cells, the limited lifespan of CAR-T cells within the body, and the constrained capacity for proliferation. Additionally, CAR-T cells face hurdles in effectively infiltrating the tumor site, which further complicates treatment outcomes. Diverse innovative strategies have been suggested to surmount these barriers in the context of CRC. </span></span><br> <span style="line-height:14.0pt"><span style="color:#231f20">This comprehensive review endeavors to meticulously elucidate an exhaustive and detailed evaluation of the prevailing and contemporary landscape concerning CAR-T cell therapy as it pertains to the intricate management of CRC, while simultaneously offering a thorough indication of the various risk factors and the associated prevalence that are intricately linked with the manifestation and progression of CRC.</span></span></span></span></p> Colorectal cancer, CAR-T cell, Treatment approaches 777 792 http://ijmcmed.org/browse.php?a_code=A-10-8020-2&slc_lang=en&sid=1 Mahyar Haki Mahyar.haki@gmail.com 100319475328460034502 0009-0007-0775-4795 No Biomedical Engineering Department, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran. Mohammad Darvishi darvishi1349@gmail.com 100319475328460034503 100319475328460034503 Yes School of Aerospace and Subaquatic Medicine, Infectious Diseases Research Center, Beasat Hospital, AJA University of Medical Sciences, Tehran, Iran.