en Cancer Cancer Review Review <span style="font-size:12px;"><span style="font-family:Tahoma;"><span style="unicode-bidi:embed"><span style="line-height:107%">Existing therapeutic interventions for controlling cancer are limited and associated with side effects. Furthermore, the recurrence of cancer poses a significant challenge to the cure of cancer. Therefore, avenues are wanted to find novel therapies for cancer treatment and cancer recurrence. In this review, we have highlighted that lactoferrin (LF) and activated protein C (APC) carry enormous potential in cancer treatment. Studies have shown that the decreased level of APC and impaired function of APC are associated with cancer progression and cancer-related mortality. Moreover, APC plays an important role in preventing prothrombotic state-mediated cancer progression and deaths. LF can also inhibit the progression of cancer by controlling the generation of reactive oxygen species, triggering the apoptosis of cancer cells, arresting the cell cycle and hindering the angiogenesis process. Additionally, APC and LF could have the potential to inhibit neutrophil extracellular traps (NETs) formations which are involved in cancer progression and the reawakening of dormant cancer cells. Hence, in this review, the anticancer potential and mechanism of APC and LF along with their potential to mitigate inflammation and NETs-mediated cancer progression and recurrence has been discussed. Additionally, possible future strategies to develop effective and safe anticancer treatment using LF and APC have also been discussed in this review.</span></span></span></span> Cancer, activated protein C, Lactoferrin, neutrophil extracellular traps, cancer treatment 86 99 http://ijmcmed.org/browse.php?a_code=A-10-6851-1&slc_lang=en&sid=1 Nahid Akhtar nahyd.akhtar24@gmail.com 100319475328460032708 100319475328460032708 No School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab-144411, India. Atif Khurshid Wani atifkhurshid61200216@gmail.com 100319475328460032709 100319475328460032709 No School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab-144411, India. Musamey Jan musameymehraj75@gmail.com 100319475328460032710 100319475328460032710 No School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab-144411, India. Shruti Sinha Sheen.shruti@gmail.com 100319475328460032711 100319475328460032711 No Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, United States of America. Hari Prasad Devkota devkotah@kumamoto-u.ac.jp 100319475328460032712 100319475328460032712 No Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan. Zijian Li jillian.li.zijian@gmail.com 100319475328460032713 100319475328460032713 No Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, United States of America. Amin-ul Mannan mannan.phd@gmail.com 100319475328460032714 100319475328460032714 No School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab-144411, India. Ajit Prakash ajit@ad.unc.edu 100319475328460032715 100319475328460032715 Yes Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, United States of America.