en Molecular & Cellular Immunology Molecular & Cellular Immunology Original Article Original Article <p><span style="font-size:12px;"><span style="font-family:Tahoma;"><span style="line-height:115%"><span sans-serif=""><span style="line-height:115%"><span new="" roman="" times="">The mRNA vaccines replace our conventional vaccines (live-attenuated and inactivated vaccines) due to their high safety, efficacy, potency and low cost for their manufacturing. Since these many years the usage of these mRNA vaccines have been restricted as there are unstable and their low efficiency in in-vivo delivery. But now, these problems have been solved by recent technological advances. Many studies conducted in animal models and humans demonstrated the good results for the mRNA vaccines. This Review provides you a detailed overview of mRNA viral vaccines and considers the current perspectives and future prospects.</span></span></span></span></span></span><br> <br> <span style="font-size:11pt"><span style="line-height:115%"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:10.0pt"><span style="line-height:115%"><span style="font-family:"Times New Roman","serif""></span></span></span></b></span></span></span></p> mRNA, vaccine, virus, lipid nanoparticle, codon optimization 260 272 http://ijmcmed.org/browse.php?a_code=A-10-5084-1&slc_lang=en&sid=1 Vasavi Koppu koppuvasavivet@gmail.com 100319475328460032619 100319475328460032619 Yes Department of Veterinary Microbiology, ICAR-IVRI, Bareilly, Uttar Pradesh, India. Deepa Poloju deepapoloju@gmail.com 100319475328460032620 0009-0006-4100-5264 No Department of Veterinary Microbiology, ICAR-IVRI, Bareilly, Uttar Pradesh, India. Bhavani Puvvala bhavanip197@gmail.com 100319475328460032621 0009-0005-2376-8957 No Department of Veterinary Microbiology, ICAR-IVRI, Bareilly, Uttar Pradesh, India. Kavitha Madineni kavithamadineni12@gmail.com 100319475328460032622 100319475328460032622 No Department of Veterinary Microbiology, ICAR-IVRI, Bareilly, Uttar Pradesh, India. Shilpa Balaji shilpabala66@gmail.com 100319475328460032623 100319475328460032623 No Department of Veterinary Microbiology, ICAR-IVRI, Bareilly, Uttar Pradesh, India. Chandana Muraleedharan Pillai Sheela cms78848@gmail.com 100319475328460032624 100319475328460032624 No Department of Veterinary Microbiology, ICAR-IVRI, Bareilly, Uttar Pradesh, India. Sri Sai Charan Manchikanti msrisaicharan421@gmail.com 100319475328460032625 0009-0005-4742-2459 No Department of Veterinary Microbiology, ICAR-IVRI, Bareilly, Uttar Pradesh, India. Moon Moon Satpathy Satpathymoon@gmail.com 100319475328460032626 100319475328460032626 No Department of Veterinary Microbiology, ICAR-IVRI, Bareilly, Uttar Pradesh, India.