en Cancer Cancer Original Article Original Article Lung cancer is the second most common cancer and has high morbidity and mortality worldwide with non-small cell lung cancer (NSCLC) accounting for 85% of the cases. Over-expression of epidermal growth factor receptor (EGFR) has been clarified in different cancers, and has been shown to have a crucial role in tumor progression. In this study, we evaluated long non-coding RNA small NF90-associated RNA (snaR) expression in different EGFR-statue cell lines. Knockdown experiments were conducted to analyze snaR expression in selected cell lines. MTT and transwell assays were respectively employed to evaluate the proliferative and invasive abilities of NSCLC cells. The expression of snaR was remarkably up-regulated in SPC-A1 and A549 wild-type EGFR cell lines. Down regulation of snaR with small interfering RNA significantly inhibited cell invasion as well as proliferation of SPC-A1 and A549 cells. Our results indicate that snaR may be a potential therapeutic biomarker for NSCLC. Long non-coding RNA, snaR, non-smallcell lung carcinoma, EGFR 258 264 http://ijmcmed.org/browse.php?a_code=A-10-4063-1&slc_lang=en&sid=1 Melika Ameli Mojard melikaamelimojarad@gmail.com 100319475328460023511 100319475328460023511 No Department of Biology, Faculty of Basic Sciences, Kharrazi University, Tehran, Iran. Mandana Ameli Mojarad mandanalee13@gmail.com 100319475328460023512 100319475328460023512 No Department of Biology, Faculty of Basic Sciences, Kharrazi University, Tehran, Iran. Alireza Pourmahdian dr.rezaamahdian@gmail.com 100319475328460023513 100319475328460023513 Yes Department of Molecular Medicine, Tehran University of Medical Sciences, Tehran, Iran.