International Journal of Molecular and Cellular Medicine
مجله بین المللی سلولی و مولکولی
Int J Mol Cell Med
Medical Sciences
http://ijmcmed.org
1
admin
2251-9637
2251-9645
10.22088/IJMCM.BUMS
en
jalali
1398
1
1
gregorian
2019
4
1
8
2
online
1
fulltext
en
The Association Analysis of Vascular Endothelial Growth Factor -2549 Insertion/Deletion Variant and Endometriosis Risk
Genetics & Disease
Genetics & Disease
Original Article
Original Article
<pre style="text-align: justify;">
Endometriosis is a debilitating disorder, defined as the presence of endometrial gland and stroma outside of the uterus. It may affect angiogenesis and vascular endothelial growth factor (VEGF) is one of the angiogenic factors that plays an important role in both physiological and pathological angiogenesis. The present study aimed to evaluate the association of <em>VEGF</em> -2549 insertion/deletion (I/D) polymorphism with endometriosis. This case-control study enrolled 244 (100 cases and 144 controls) women who were admitted for laparoscopy or laparotomy for gynecological procedures. Genomic DNA was separated from peripheral blood leukocytes and polymerase chain reaction amplification was performed for genotyping of the <em>VEGF</em> gene Insertion/Deletion (I/D) polymorphism. The frequency of the II, ID, and DD genotype was 14%, 52% and 34% in patients versus 18.8%, 47.8% and 34% in controls. The results did not provide any evidence supporting the endometriosis risk related to the <em>VEGF</em> polymorphism in Iranian women population.
</pre>
Endometriosis, vascular endothelial growth factor, VEGF, -2549 I/D, polymorphism
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68
http://ijmcmed.org/browse.php?a_code=A-10-1798-1&slc_lang=en&sid=1
Negar
Sarhangi
nsarhangi198@gmail.com
100319475328460016532
100319475328460016532
No
Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Shahrzad
Mohseni
shmohseni58@gmail.com
100319475328460016533
100319475328460016533
No
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Soheila
Aminimoghaddam
aminimoghaddam.s@iums.ac.ir
100319475328460016534
100319475328460016534
No
Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran.
Batool
Hossein Rashidi
bhrashidi@gmail.com
100319475328460016535
100319475328460016535
No
Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Fedyeh
Haghollahi
fedyeh_hagh@yahoo.com
100319475328460016536
100319475328460016536
No
Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran.
Mostafa
Qorbani
mqorbani1379@yahoo.com
100319475328460016537
100319475328460016537
No
Department of Community Medicine, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Mahsa
Mohammad Amoli
amolimm@tums.ac.ir
100319475328460016538
100319475328460016538
No
Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Maryam
Shahrabi-Farahani
maryam_shahrabif@yahoo.com
100319475328460016539
100319475328460016539
Yes
Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.