en Stem Cell Stem Cell Review Review <div style="text-align: justify;">Various mesenchymal stem cells as easily accessible and multipotent cells can share different essential signaling pathways related to their stemness ability. Understanding the mechanism of stemness ability can be useful for controlling the stem cells for regenerative medicine targets. In this context, OMICs studies can analyze the mechanism of different stem cells properties or stemness ability via a broad range of current high-throughput techniques. This field is fundamentally directed toward the analysis of whole genome (genomics), mRNAs (transcriptomics), proteins (proteomics) and metabolites (metabolomics) in biological samples. According to several studies, metabolomics is more effective than other OMICs <strong><span dir="RTL">ّ</span></strong>for various systems biology concerns. Metabolomics can elucidate the biological mechanisms of various mesenchymal stem cells function by measuring their metabolites such as their secretome components. Analyzing the metabolic alteration of mesenchymal stem cells can be useful to promote their regenerative medicine application.</div> Mesenchymal stem cells, metabolic pathways, metabolomics, systems biology 30 40 http://ijmcmed.org/browse.php?a_code=A-10-1797-2&slc_lang=en&sid=1 Parisa Goodarzi pr_goodarzi@yahoo.com 100319475328460015259 100319475328460015259 No Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. Sepideh Alavi-Moghadam sepidalavi@gmail.com 100319475328460015260 100319475328460015260 No Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Moloud Payab moloud.payab@gmail.com 100319475328460015261 100319475328460015261 No Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Bagher Larijani larijanib1340@gmail.com 100319475328460015262 100319475328460015262 No Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical sciences, Tehran, Iran. Fakher Rahim bioinfo2003@gmail.com 100319475328460015263 100319475328460015263 No Health Research Institute, Thalassemia and Hemoglobinopathies Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Kambiz Gilany k.gilany@ari.ir 100319475328460015264 100319475328460015264 No Integrative Oncology Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran; Department of Biomedical Sciences, University of Antwerp, Belgium. Nikoo Bana Niko_bana@yahoo.com 100319475328460015265 100319475328460015265 No Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular- Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Akram Tayanloo-Beik A.tayanloo@gmail.com 100319475328460015266 100319475328460015266 No Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Najmeh Foroughi Heravani najmeh_foroughi@yahoo.com 100319475328460015267 100319475328460015267 No Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Mahdieh Hadavandkhani mahdiehhadavandkhani1376@yahoo.com 100319475328460015268 100319475328460015268 No Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Babak Arjmand barjmand@sina.tums.ac.ir 100319475328460015269 100319475328460015269 Yes Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.