en Other Other Letters to the editor Letters to the editor <div style="text-align: justify;">The gene therapy approach has largely been improved by the development of new methods in gene transfer and genome editing. The use of CART cells was first approved in 2018 by FDA for <em>ex vivo</em> treatment of B cell acute lymphoblastic leukemia and <em>in vivo</em> treatment of retinal dystrophy. This revolutionary trend is expected to continue as the clinical vision develops and the technical capacity improves.</div> Gene Therapy, Genome Editing 69 70 http://ijmcmed.org/browse.php?a_code=A-10-1795-4&slc_lang=en&sid=1 Mandana Hasanzad mandanahasanzad@yahoo.com 100319475328460016540 100319475328460016540 No Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Bagher Larijani Larijanib1340@gmail.com 100319475328460016541 100319475328460016541 Yes Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.