RT - Journal Article T1 - Relationship of Podoplanin and Glutathione S-transferases T1 Expression with Laryngeal Cancer JF - ijmcmed YR - 2012 JO - ijmcmed VO - 1 IS - 4 UR - http://ijmcmed.org/article-1-53-en.html SP - 217 EP - 224 K1 - Podoplanin K1 - GST-T1 K1 - laryngeal carcinoma K1 - biomarker K1 - squamous cell carcinoma AB - The aim of this study is to determine whether there is a role of podoplanin and glutathione S-transferases T1 (GST-T1) expression in laryngeal squamous cell carcinoma. The study was completed with 33 patients and gene expression analysis was performed by qRT–PCR. The podoplanin and GST-T1 expression patterns were analyzed to determine their correlation with clinicopathologic parameters of laryngeal cancer. Of all patients, 20 had supraglottic, and the remaining 13 had glottic laryngeal cancer. Increased expression of podoplanin was found in 14 tumor tissues, but GST-T1 expression was not detected. Podoplanin expression did not show any prediction for regional metastasis, thyroid cartilage invasion, lymphatic vessel invasion or tumor differentiation for laryngeal cancer, also there were no significant differences in podoplanin expression between glottic and supraglottic regions, but extracapsullar extension is almost statistically significant (p=0,05). LA eng UL http://ijmcmed.org/article-1-53-en.html M3 ER -