RT - Journal Article T1 - Cleft Palate induced by Sulfur Mustard in mice fetus JF - ijmcmed YR - 2012 JO - ijmcmed VO - 1 IS - 1 UR - http://ijmcmed.org/article-1-36-en.html SP - 39 EP - 43 K1 - Sulfur Mustard K1 - teratogenicity K1 - cleft lip/palate AB - Sulfur Mustard (SM) is a chemical warfare agent which was widely used in the World War I and more recently during Gulf war in the early 1980s'. SM is a strong alkylating agent with known mutagenic and carcinogenic effects but only few studies have been published on its teratogenicity. Since SM has been widely used as a chemical weapon by the Iraqi regime against the Iranian soldiers as well as the civilian population particularly pregnant women in the border area therefore, the investigation of SM adverse effects on cleft malformations which is one of the most frequent congenital anomalies is considered in this study. An experimental work has been carried out in embryopathy in mouse with intraperitoneal injection of 0.75 and 1.5 mg/kg SM at different periods of gestation. Cleft lip and palate were examined by stereomicroscopy. Current data demonstrate that exposure with SM on the 11th day of gestation can increase the incidence of cleft defects in comparison with control group (P LA eng UL http://ijmcmed.org/article-1-36-en.html M3 ER -