TY - JOUR T1 - Analysis of rs6725887 in the WD Repeat Protein 12 in Association With Coronary Artery Disease in Iranian Patients TT - JF - ijmcmed JO - ijmcmed VL - 4 IS - 3 UR - http://ijmcmed.org/article-1-341-en.html Y1 - 2015 SP - 160 EP - 166 KW - Atherosclerosis KW - WDR12 gene KW - polymorphism KW - risk factor KW - Iranian N2 - Although genetic variants that affect susceptibility to coronary artery disease (CAD) have been greatly known, a number of these single nucleotide polymorphisms (SNPs) remain to be analyzed in populations with different ethnicities. CAD is influenced by numerous genetic, environmental, and lifestyle factors, and is an important reason for mortality around the globe. In this study, a novel SNP (rs6725887) in the WD Repeat Protein 12 (WDR12) gene was selected to be examined in Iranian patients with CAD. Ninety eigth healthy controls and one hundred and one CAD patients were enrolled from Iranian population, and their clinical data were collected for further comparisons. After DNA extraction from each sample, genotypes were characterized by Taq Man probe real- time PCR assay. Statistical analyses were performed to evaluate genotype and allele frequencies and compared the values with clinical variables. Body mass index, blood pressure, fasting blood sugar, LDL, HDL, cholesterol, and triglyceride significantly differed in CAD and control groups. Genotype and allele frequencies of rs6725887 in CAD patients and controls showed no significant association in the distribution. However, clinical parameters of CAD patients like HDL, LDL, FBS, TG, DBP and SBP had significantly (P M3 ER -