TY - JOUR JF - ijmcmed JO - Int J Mol Cell Med VL - 10 IS - 3 PY - 2021 Y1 - 2021/8/01 TI - Role of mTOR Complex 1 Signaling Pathway in the Pathogenesis of Diabetes Complications; A Mini Review TT - N2 - The mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine-protein kinase that senses and combines various environmental signals to regulate the growth and homeostasis of human cells. This signaling pathway synchronizes many critical cellular processes and is involved in an increasing number of pathological conditions such as diabetes, cancer, obesity, and metabolic syndrome. Here, we review different complications of diabetes that are associated with mTOR complex 1 imbalance. We further discuss pharmacological approaches to treat diabetes complications linked to mTOR deregulation. SP - 181 EP - 188 AU - Yarahmadi, Amir AU - Azarpira, Negar AU - Mostafavi-Pour, Zohreh AD - Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. KW - Diabetes KW - complications KW - mTOR KW - mTOR complex 1 KW - signaling UR - http://ijmcmed.org/article-1-1707-en.html DO - 10.22088/IJMCM.BUMS.10.3.181 ER -