@ARTICLE{Eissa, author = {Elnady, Hala Gouda and Sherif, Lobna Sayed and Kholoussi, Naglaa Mohamed and Azzam, Mona Ali and Foda, Ahmed Rashad and Helwa, Iman and Sabry, Rania Nabil and Eissa, Eman and Fahmy, Reham Faisal and }, title = {Aberrant Expression of Immune-related MicroRNAs in Pediatric Patients with Asthma}, volume = {9}, number = {4}, abstract ={MicroRNAs (miRNAs) have been implicated as regulatory molecules that could play a considerable role in the pathogenesis of different diseases including asthma. This work aims at exploring the role of miR-146a and miR-106b in the pathogenesis of asthma and their association with asthma severity, IgE, and inflammatory cytokines in asthmatic children. Thirty asthmatic children and twenty age-matched healthy children aged 4-17 years old were enrolled. Expression of plasma miR-146a and miR-106b was measured using quantitative real-time PCR. Plasma levels of interleukin-5 (IL-5) and interleukin-13 (IL-13) were assessed using ELISA. Lung functions were measured by Spirometry. MiR-146a and miR-106b were significantly over-expressed in asthmatic children compared to healthy children. A significant positive correlation between total IgE and both miR-146a and miR-106b was found while no significant correlation could be detected between these miRNAs and asthma severity in asthmatic children. Plasma levels of IL-5 and IL-13 were non-significantly higher in asthmatic children compared to healthy children, and there was no significant correlation between them and both miR-146a and miR-106b expressions in the asthmatic children. The aberrant expression of immune-related miRNAs (miR-146a and miR-106b) and inflammatory cytokines (IL-5 and IL-13) among asthmatic children suggest their probable role in asthma pathogenesis. }, URL = {http://ijmcmed.org/article-1-1437-en.html}, eprint = {http://ijmcmed.org/article-1-1437-en.pdf}, journal = {International Journal of Molecular and Cellular Medicine}, doi = {10.22088/IJMCM.BUMS.9.4.246}, year = {2020} }