TY - JOUR JF - ijmcmed JO - Int J Mol Cell Med VL - 9 IS - 3 PY - 2020 Y1 - 2020/8/01 TI - Plasma Levels of miR-27a, miR-130b, and miR-301a in Polycystic Ovary Syndrome TT - N2 - Polycystic ovary syndrome (PCOS) is a gynecological endocrine disorder in women of reproductive age. There is adequate evidence that suggests several microRNAs (miRNAs) are of great importance for PCOS. It seems that dysregulated expression of miR-27a, miR-130b, and miR-301a are associated with PCOS. The aim of this study was to investigate whether plasma levels of these miRNAs are different between patients with PCOS and healthy controls. 53 women with a definite diagnosis of PCOS, and 53 healthy controls were enrolled. MiRNAs expression levels in plasma were evaluated by real-time PCR. The diagnostic values of each miRNA were calculated by the receiver operating characteristic (ROC) curve and areas under the curves (AUC). The main clinical characteristics were not significantly different between the two groups. The circulating plasma expression levels of miR-27a and miR-301a had a significant increase (P = 0.0008 and P < 0.0001, respectively) but miR-130b expression level decreased in the patient group (P < 0.0001). The AUC for miR-27a, miR-130b, and miR-301a were 0.71, 0.77, and 0.66, respectively. A positive exponential was observed for miR-27a and miR-301a in multiple logistic regression. Changes in the plasma expressions of the studied miRNAs are likely to be associated with PCOS phenotypes. MiR-27a has a potential to serve as a diagnostic biomarker of PCOS. SP - 198 EP - 206 AU - Pourteymour Fard Tabrizi, Zahra AU - Miraj, Sepideh AU - Tahmasebian, Shahram AU - Ghasemi, Sorayya AD - Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran. KW - Polycystic ovary syndrome KW - plasma KW - miRNA-27a KW - miRNA-130b KW - miRNA-301a UR - http://ijmcmed.org/article-1-1272-en.html DO - 10.22088/IJMCM.BUMS.9.3.198 ER -