@ARTICLE{E. Ayoub, author = {E. Ayoub, Shymaa and G. Shaker, Olfat and Y. Abdelwahed, Mostafa and A. Ahmed, Naglaa and G. Abdelhameed, Hazem and H. Bosilah, Almandouh and R. Mohammed, Sheren and }, title = {Association of MicroRNA-155 rs767649 polymorphism with Susceptibility to Preeclampsia}, volume = {8}, number = {4}, abstract ={Preeclampsia (PE) is a multifactorial disorder. Several studies showed that micro RNAs may play a critical role in PE pathogenesis. We aimed to investigate for the first time the association of mir-155rs767649 polymorphism with PE. Eighty patients with preeclampsia and 80 normal subjects were enrolled in the study. Serum expression levels of mature mir-155were evaluated using real-time PCR, and mir-155 rs767649 (T/A) polymorphism was genotyped using TaqMan SNP genotyping. There was a significant difference between the expression level of mir-155 in cases (5.86 ± 3.11) in comparison with controls (0.58 ± 0.30) (P<0.0001). Also,the minor allele of rs767649 was significantly associated with increased risk of PE [Recessive model: adjusted Odds ratio (OR) = 5.240, 95% confidence interval (CI) = (1.999-13.733),P= 0.001]. There was a significant difference between different genotypes according to expression levels of mir-155 in PE (P<0.0001) with high expression levels in TA genotype (7.10 ± 3.11 ). Mir-155 may play a critical role in PE pathogenesis. The obtained data suggest that a minor allele of rs767649 might be a predisposing factor for PE. }, URL = {http://ijmcmed.org/article-1-1171-en.html}, eprint = {http://ijmcmed.org/article-1-1171-en.pdf}, journal = {International Journal of Molecular and Cellular Medicine}, doi = {10.22088/IJMCM.BUMS.8.4.247}, year = {2019} }