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:: دوره 8، شماره 2 - ( 4-1398 ) ::
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Gastric Cancer MicroRNAs Meta-signature
:   (256 مشاهده)
Gastric cancer (GC) is one of the most common types of cancer and the second leading cause of cancer-associated mortality. Identification of novel biomarkers is critical to prolonging patient survival. MicroRNAs (miRNAs) proved to play diverse roles in the physiological and pathological state in cancers including GC. Herein we were aimed at performing a meta-analysis on miRNA profiling studies that used microarray platforms. Relevant studies were retrieved from PubMed and GEO databases. We used the robust rank aggregation to perform the meta-analysis. Moreover, for meta-signature miRNAs target genes, we performed pathway enrichment and GO molecular function enrichment analysis. A total of 19 upregulated miRNAs and seven downregulated miRNAs in GC samples were identified. However, only three upregulated and one downregulated miRNA reached statistical significance after multiple test correction. Here we showed that hsa-miR-21-5p, hsa-miR-93-5p, hsa-miR-25-3p, and hsa-miR-375 are differentially expressed in GC samples.
     
نوع مطالعه: Review | موضوع مقاله: Cancer
دریافت: ۱۳۹۷/۱۰/۲۶ | پذیرش: ۱۳۹۸/۵/۲۳
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Zare A, Ganji M, Omrani M D, Alipoor B, Ghaedi H. Gastric Cancer MicroRNAs Meta-signature. Int J Mol Cell Med. 2019; 8 (2)
URL: http://ijmcmed.org/article-1-989-fa.html

Gastric Cancer MicroRNAs Meta-signature. مجله بین المللی سلولی و مولکولی. 1398; 8 (2)

URL: http://ijmcmed.org/article-1-989-fa.html



دوره 8، شماره 2 - ( 4-1398 ) برگشت به فهرست نسخه ها
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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