:: Volume 8, Issue 2 (Int J Mol Cell Med 2019) ::
Int J Mol Cell Med 2019, 8(2): 94-102 Back to browse issues page
Gastric Cancer MicroRNAs Meta-signature
Ali Zare1 , Maziar Ganji1 , Mir Davood Omrani2 , Behnam Alipoor3 , Hamid Ghaedi 4
1- Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3- Department of Laboratory Sciences, Faculty of Para medicine, Yasuj University of Medical Sciences, Yasuj, Iran.
4- Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , h.qaedi@sbmu.ac.ir
Abstract:   (1433 Views)
Gastric cancer (GC) is one of the most common types of cancer and the second leading cause of cancer-associated mortality. Identification of novel biomarkers is critical to prolonging patient survival. MicroRNAs (miRNAs) proved to play diverse roles in the physiological and pathological state in cancers including GC. Herein we were aimed at performing a meta-analysis on miRNA profiling studies that used microarray platforms. Relevant studies were retrieved from PubMed and GEO databases. We used the robust rank aggregation to perform the meta-analysis. Moreover, for meta-signature miRNAs target genes, we performed pathway enrichment and GO molecular function enrichment analysis. A total of 19 upregulated miRNAs and seven downregulated miRNAs in GC samples were identified. However, only three upregulated and one downregulated miRNA reached statistical significance after multiple test correction. Here we showed that hsa-miR-21-5p, hsa-miR-93-5p, hsa-miR-25-3p, and hsa-miR-375 are differentially expressed in GC samples.
Keywords: gastric cancer, microRNA, GO enrichment, biomarkers
Full-Text [PDF 391 kb]   (207 Downloads)    
Type of Study: Review | Subject: Cancer
Received: 2019/01/16 | Accepted: 2019/08/14 | Published: 2020/02/5



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Volume 8, Issue 2 (Int J Mol Cell Med 2019) Back to browse issues page