Evaluation of Ameliorative Potential of Vitamins E and C on DNA Double Strand Break (DSB) in Patients Undergoing Computed Tomography (CT): A Clinical Study
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Seyed Masoud Jafarpour1 , Morteza Salimian2 , Mehran Mohseni 3, Hamid Reza Talari4 , Akbar Aliasgharzadeh1 , Bagher Farhood1 , Habiballah Moradi1 , Hossein Safari5 |
1- Department of Radiology and Medical Physics, Faculty of Paramedicine, Kashan University of Medical Sciences, Kashan, Iran. 2- Department of Medical laboratory, Faculty of Paramedicine, Kashan University of Medical Sciences, Kashan, Iran. 3- Department of Radiology and Medical Physics, Faculty of Paramedicine, Kashan University of Medical Sciences, Kashan, Iran. , mehran.m1352@yahoo.com 4- Department of Radiology, Kashan University of Medical Sciences, Kashan, Iran. 5- Health promotion research center, Iran University of Medical Sciences, Tehran, Iran. |
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Abstract: (5193 Views) |
Computed tomography (CT) is one of the most important diagnostic X-ray procedures which plays an important role in increasing the patient dose values. The purpose of this clinical study was to evaluate the efficacy of vitamins E and C in lowering down the level of DNA double strand break (DSB) caused by CT scan. Sixty patients for abdomen/pelvic enhanced CT scan were randomly assigned to placebo (control), vitamin C, and vitamin E groups. The patient blood samples were taken before and immediately after the CT scan. Counting the number of DSB was performed using γ-H2AX method as a sensitive biomarker. Immediately after the CT scan, the mean number of DSBs/cell increased in all three groups of control (131%, P < 0.001), vitamin C (103%, P < 0.001), and vitamin E (66%, P < 0.001) compared to their mean before the CT scan. Furthermore, the results showed that vitamin E decreased the mean number of DSBs/cell by 22% in comparison with the control group (P = 0.023), whereas vitamin C had no significant effect on reducing the DSB (<3%, P = 0.741). It is concluded that the administration of vitamin E one hour before the CT scan, significantly decreases DSB levels. |
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Keywords: Computed tomography (CT), DNA double strand break (DSB), vitamin C, vitamin E |
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Full-Text [PDF 397 kb]
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Type of Study: Original Article |
Subject:
Other Received: 2018/10/20 | Accepted: 2019/02/24 | Published: 2019/07/5
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