:: Volume 7, Issue 4 (Int J Mol Cell Med 2018) ::
Int J Mol Cell Med 2018, 7(4): 226-233 Back to browse issues page
Evaluation of Ameliorative Potential of Vitamins E and C on DNA Double Strand Break (DSB) in Patients Undergoing Computed Tomography (CT): A Clinical Study
Seyed Masoud Jafarpour1, Morteza Salimian2, Mehran Mohseni 3, Hamid Reza Talari4, Akbar Aliasgharzadeh1, Bagher Farhood1, Habiballah Moradi1, Hossein Safari5
1- Department of Radiology and Medical Physics, Faculty of Paramedicine, Kashan University of Medical Sciences, Kashan, Iran.
2- Department of Medical laboratory, Faculty of Paramedicine, Kashan University of Medical Sciences, Kashan, Iran.
3- Department of Radiology and Medical Physics, Faculty of Paramedicine, Kashan University of Medical Sciences, Kashan, Iran. , mehran.m1352@yahoo.com
4- Department of Radiology, Kashan University of Medical Sciences, Kashan, Iran.
5- Health promotion research center, Iran University of Medical Sciences, Tehran, Iran.
Abstract:   (654 Views)
Computed tomography (CT) is one of the most important diagnostic X-ray procedures which plays an important role in increasing the patient dose values. The purpose of this clinical study was to evaluate the efficacy of vitamins E and C in lowering down the level of DNA double strand break (DSB) caused by CT scan. Sixty patients for abdomen/pelvic enhanced CT scan were randomly assigned to placebo (control), vitamin C, and vitamin E groups. The patient blood samples were taken before and immediately after the CT scan. Counting the number of DSB was performed using γ-H2AX method as a sensitive biomarker. Immediately after the CT scan, the mean number of DSBs/cell increased in all three groups of control (131%, P < 0.001), vitamin C (103%, P < 0.001), and vitamin E (66%, P < 0.001) compared to their mean before the CT scan. Furthermore, the results showed that vitamin E decreased the mean number of DSBs/cell by 22% in comparison with the control group (P = 0.023), whereas vitamin C had no significant effect on reducing the DSB (<3%, P = 0.741). It is concluded that the administration of vitamin E one hour before the CT scan, significantly decreases DSB levels.
Keywords: Computed tomography (CT), DNA double strand break (DSB), vitamin C, vitamin E
Full-Text [PDF 397 kb]   (78 Downloads)    
Type of Study: Original Article | Subject: Other
Received: 2018/10/20 | Accepted: 2019/02/24 | Published: 2019/07/5



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Volume 7, Issue 4 (Int J Mol Cell Med 2018) Back to browse issues page