:: Volume 7, Issue 2 (Int J Mol Cell Med 2018) ::
Int J Mol Cell Med 2018, 7(2): 80-90 Back to browse issues page
Hydroxyapatite from Fish for Bone Tissue Engineering: A Promising Approach
Renata Neves Granito 1, Ana Claudia Renno 1, Hirochi Yamamura 2, Matheus Cruz de Almeida 1, Pedro Luiz Menin Ruiz 1, Daniel Araki Ribeiro * 3
1- Department of Biosciences, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil.
2- Department of Chemistry, Catholic University of Santos, UNISANTOS, Santos, SP, Brazil.
3- Department of Biosciences, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil. , daribeiro@unifesp.br
Abstract:   (1297 Views)

Natural or synthetic hydroxyapatite (HA) has been frequently used as implant materials for orthopaedic and dental applications, showing excellent bioactivity, adequate mechanical rigidity and structure, osteoconductivity and angiogenic properties, no toxicity, and absence of inflammatory or antigenic reactions. HA can be easily synthesized or extracted from natural sources, such as bovine bone. However, the manufacturing costs to obtain HA are high, restricting the therapy. Herein, much effort has been paid for obtaning alternative natural sources for HA. The potential of HA extracted from skeleton of animals has been investigated. The aim of this review is to exploit the potential of HA derived from fish to fulfill biological activities for bone tissue engineering. In particular, HA from fish is easy to be manufactured regarding that the majority of protocols are based on the calcination method. Furthermore, the composition and structure of HA from fish were evaluated; the biomaterial showed good biocompatibility as a result of non-cytotoxicity and handling properties, demonstrating advantages in comparison with synthetic ones. Interestingly, another huge benefit brought by HA from bone fish is its positive effect for environment since this technique considerably reduces waste. Certainly, the process of transforming fish into HA is an environmentally friendly process and stands as a good chance for reducing costs of treatment in bone repair or replacement with little impact into the environment.

Keywords: hydroxyapatite, review, fish waste, tissue engeneering
Full-Text [PDF 210 kb]   (366 Downloads)    
Type of Study: Mini-review | Subject: Other
Received: 2018/03/5 | Accepted: 2018/06/20 | Published: 2018/06/28

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Volume 7, Issue 2 (Int J Mol Cell Med 2018) Back to browse issues page