[صفحه اصلی ]   [Archive]  
:: صفحه اصلي :: درباره نشريه :: آخرين شماره :: تمام شماره‌ها :: جستجو :: ثبت نام :: ارسال مقاله :: تماس با ما ::
:: دوره 7، شماره 2 - ( 2-1397 ) ::
برگشت به فهرست نسخه ها
The Growth Arrest-Specific Transcript 5 (GAS5) and Nuclear Receptor Subfamily 3 Group C Member 1 (NR3C1): Novel Markers Involved in Multiple Sclerosis
:   (342 مشاهده)
Recent studies have revealed that long non-coding RNAs (lncRNAs) are connected with pathogenesis of neurodegenerative diseases. Additionally, glucocorticoids have fundamental regulatory roles on the immune system, and act as potent therapeutic compounds for autoimmune and inflammatory diseases. The long noncoding RNA growth arrest-specific 5 (GAS5) which accumulates inside the cells in response to cellular starvation/growth arrest, acts as a potent repressor of the glucocorticoid receptor (GR) through its glucocorticoid response element (GRE). The aim of the present study was to investigate the role of lncRNA GAS5 and its downstream target Nuclear Receptor Subfamily 3 Group C Member 1(NR3C1) in the pathogenesis of multiple sclerosis (MS), and to define the role of GAS5 in the regulation of NR3C1 expression. Quantitative polymerase chain reaction was performed for investigating the expression of GAS5 and NR3C1 in MS patients and healthy subjects. We found that GAS5 levels were up-regulated in blood of MS patients compared with healthy subjects in correlation with NR3C1 expression. Our findings suggest that GAS5 may play important role in the molecular etiology and treatment of MS.
     
نوع مطالعه: Original Article | موضوع مقاله: Genetics & Disease
دریافت: ۱۳۹۶/۱۲/۵ | پذیرش: ۱۳۹۶/۱۲/۲۱ | انتشار: ۱۳۹۷/۲/۱۷
ارسال نظر درباره این مقاله
نام کاربری یا پست الکترونیک شما:

کد امنیتی را در کادر بنویسید >


XML   English Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Gharesouran J, Taheri M, Sayad A, Ghafouri-Fard S, Mazdeh M, Omrani M D. The Growth Arrest-Specific Transcript 5 (GAS5) and Nuclear Receptor Subfamily 3 Group C Member 1 (NR3C1): Novel Markers Involved in Multiple Sclerosis. Int J Mol Cell Med. 2018; 7 (2)
URL: http://ijmcmed.org/article-1-821-fa.html

The Growth Arrest-Specific Transcript 5 (GAS5) and Nuclear Receptor Subfamily 3 Group C Member 1 (NR3C1): Novel Markers Involved in Multiple Sclerosis. مجله بین المللی سلولی و مولکولی. 1397; 7 (2)

URL: http://ijmcmed.org/article-1-821-fa.html



دوره 7، شماره 2 - ( 2-1397 ) برگشت به فهرست نسخه ها
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
Persian site map - English site map - Created in 0.06 seconds with 31 queries by YEKTAWEB 3701