:: Volume 7, Issue 1 (Int J Mol Cell Med [In press] 2018) ::
Int J Mol Cell Med 2018, 7(1): 1-7 Back to browse issues page
Association between Long Noncoding RNA ANRIL Expression Variants and Susceptibility to Coronary Artery Disease
Mohsen Yari 1, Sara Bitarafan 1, Mohammad Ali Broumand 2, Zahra Fazeli 1, Mahnoosh Rahimi 1, Sayyed Mohammad Hossein Ghaderian 1, Reza Mirfakhraie 1, Mir Davood Omrani * 3
1- Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Department of Molecular Pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
3- Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , davood_omrani@sbmu.ac.ir
Abstract:   (1282 Views)
Animal cells possess thousands of long non-coding (lnc) RNAs, such as antisense noncoding RNA in the INK4 locus (ANRIL) , which have regulatory roles in the cells’ molecular mechanisms, including X-chromosome inactivation, and developmental processes.  These lnc RNAs are known to influence the extensive spectrum of age-related disorders. Accordingly, there is evidence for the role of these lnc RNAs in cardiovascular diseases, particularly coronary artery diseases (CAD). The aim of this study was to assess whether the expression of the lnc RNA ANRIL was associated with a susceptibility to CAD by evaluating the expression level of the two transcripts of ANRIL. Peripheral blood was taken from fifty patients affected by CAD and relative expression of ANRIL was  determined by Real-Time PCR assay. The obtained data indicated that the EU741058 transcript expression level was significantly decreased in CAD patients in comparison with the healthy individuals (P= 0.001). Furthermore, there was no significant association between the NR_003529 transcript expression, and CAD risk in Iranian patients (P= 0.751). Our results suggest that the expression level of the EU741058 transcript of ANRIL may be implicated in CAD development, creating a predictive biomarker for CAD patients in future.
Keywords: Coronary artery disease, atherosclerosis, long noncoding RNA, ANRIL, chromosome 9p21
Full-Text [PDF 401 kb]   (223 Downloads)    
Type of Study: Original Article | Subject: Genetics & Disease
Received: 2017/09/15 | Accepted: 2018/01/6 | Published: 2018/02/10



XML     Print



Volume 7, Issue 1 (Int J Mol Cell Med [In press] 2018) Back to browse issues page