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:: Volume 6, Number 3 (Int J Mol Cell Med (In press) 2017) ::
Int J Mol Cell Med 2017, 6(3): 0-0 Back to browse issues page
Polymorphisms of Antioxidant’ Genes as a Target for Diabetes Management
Ozra Tabatabaei-Malazy1, Mehrnoosh Khodaeian2, fatemeh Bitarafan3, Bagher Larijani2, Mahsa M.Amoli *4
1- Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran., Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
2- Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran., TehranEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
3- Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran., Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
4- Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran., TehranMetabolic Disorders Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. , amolimm@tums.ac.ir
Abstract:   (585 Views)

Diabetes mellitus (DM) is one of the most important health problems with increasing prevalence worldwide. Oxidative stress that is a result of imbalance between reactive oxygen species (ROS) generation and antioxidant defense mechanisms has been demonstrated as a main pathology in DM. Hyperglycemia-induced ROS productions can induce oxidative stress through four major molecular mechanisms including, the polyol pathway, advanced glycation end-products formation, activation of protein kinase C isoforms, and the hexosamine pathways. In development of type 2 DM (T2DM) and its complications, genetic and environmental factors play important roles. Therefore, the aim of this review is to focus on assessment of single-nucleotide polymorphisms within antioxidant enzymes including superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, nitric oxide synthase, and NAD(P)H oxidase and their association with T2DM. The results will be helpful in understanding the mechanisms involved in pathogenesis of disease besides discovering new treatment approaches in management of DM.

Keywords: Diabetes mellitus, oxidative stress, antioxidants, polymorphism
     
Type of Study: Review | Subject: Genetics & Disease
Received: 2017/03/13 | Accepted: 2017/06/29 | Published: 2017/08/14
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Tabatabaei-Malazy O, Khodaeian M, Bitarafan F, Larijani B, M.Amoli M. Polymorphisms of Antioxidant’ Genes as a Target for Diabetes Management. Int J Mol Cell Med. 2017; 6 (3)
URL: http://ijmcmed.org/article-1-667-en.html
Volume 6, Number 3 (Int J Mol Cell Med (In press) 2017) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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