:: Volume 5, Number 4 (Int J Mol Cell Med 2016) ::
Back to browse issues page Int J Mol Cell Med 2016, 5(4): 229-235
A Comparison Between the Effect of Cuminumcyminumand Vitamin E on the Level of Leptin, Paraoxonase 1, HbA1c and Oxidized LDL in Diabetic Patients
Keihan Ghatreh Samani *1, Mohammad hossein Gharib2, Ali Momeni3, Zohreh Hemati4, Roya Sedighin4
1- Clinical BiochemistryResearch Center, Shahrekord University of Medical Sciences, Shahrekord, Iran., Clinical BiochemistryResearch Center, Shahrekord University of Medical Sciences, Shahrekord, Iran. , kgsamani@yahoo.com
2- Clinical BiochemistryResearch Center, Shahrekord University of Medical Sciences, Shahrekord, Iran., Clinical BiochemistryResearch Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
3- Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran., Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
4- Shahrekord University of Medical Sciences, Shahrekord, Iran., Shahrekord University of Medical Sciences, Shahrekord, Iran.
Abstract:   (452 Views)

Diabetes is one of the most common metabolic diseases in the world. Vitamin E reduces protein glycation and improves insulin sensitivity, while cumin is effective in remission of diabetes. Therefore this study was designed to evaluate the effects of vitamin E and cumin essential oil, on the blood level of leptin,glycosylated hemoglobin (HbA1C) and also on lipid profile in diabetic patients.In this double blind clinical trial, 95 diabetic patients were selected and randomly dividedinto three groups.The first group received cumin essential oil in capsule form. The second group received Vitamin E, and the third group was used ascontrol receiving oral gelatin capsules as placebo for three months period.Blood glucose, lipid profile, apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), leptin, HbA1c, oxidized LDL (oxLDL), and paraoxonase1 activity were measured. The results showed reduction in oxLDL and significant increase in paraoxonase 1 in Vitamin E group by the end of the third month period (P<0.05). Cumin group showed decrease in blood glucose, HbA1C, triglyceride, leptin and ox-LDL. ApoA1 and paraoxonase1 were also increased by cumin treatment (P<0.05).Diabetic complications may have been reduced by intake of Vitamin E and cumin essential oil. Cumin in comparison with vitamin E has broader impact and it is more beneficial in terms of ability to reduce the diabetic index.

Keywords: Diabetes, vitamin E, cumin, leptin, Paraoxonase 1, oxLDL
Full-Text [PDF 108 kb]   (184 Downloads)    
Type of Study: Original Article | Subject: Clinical Biochemistry
Received: 2016/11/22 | Accepted: 2017/01/8 | Published: 2017/01/14



DOI: 10.22088/acadpub.BUMS.5.4.229


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Back to browse issues page Volume 5, Number 4 (Int J Mol Cell Med 2016)