[صفحه اصلی ]   [Archive]  
:: صفحه اصلي :: درباره نشريه :: آخرين شماره :: تمام شماره‌ها :: جستجو :: ثبت نام :: ارسال مقاله :: تماس با ما ::
:: دوره 5، شماره 3 - ( 4-1395 ) ::
برگشت به فهرست نسخه ها
MAP3K1 May be a Promising Susceptibility Gene for Type 2 Diabetes Mellitus in an Iranian Population
:   (2457 مشاهده)

Considering that MAPK (mitogen- activated protein kinase) signaling pathway has an important role in the progression of inflammatory cytokine secretion in type 2 diabetes mellitus (T2DM), we have recently investigated the reported genetic polymorphism from genome wide association study in MAP3K1 (mitogen-activated protein kinase kinase kinase 1) in diabetes as an important member of MAPK signaling. This study aimed to investigate the possible association of rs10461617 at the upstream of MAP3K1 gene in an Iranian case-control study with the risk of T2DM. The study population was comprised of 342 unrelated Iranian individuals including 177 patients with T2DM and 165 unrelated healthy control subjects. Genotyping was performed using PCR-RFLP and confirmed with sequencing. In a logistic regression analysis, the rs10461617A allele was associated with a significantly higher risk of T2DM assuming the log- additive model (OR: 1.44, 95% CI: 1.01-2.05, P = 0.039). In conclusion, we provided the first evidence for the association of rs10461617 at the upstream of MAP3K1 with the risk of T2DM in an Iranian population.

متن کامل [PDF 101 kb]   (1161 دریافت)    
نوع مطالعه: Original Article | موضوع مقاله: Genetics & Disease
دریافت: ۱۳۹۵/۳/۱۲ | پذیرش: ۱۳۹۵/۴/۱۲ | انتشار: ۱۳۹۵/۵/۳۱
ارسال نظر درباره این مقاله
نام کاربری یا پست الکترونیک شما:

کد امنیتی را در کادر بنویسید >



DOI: 10.22088/acadpub.BUMS.5.3.134


XML   English Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Torkamandi S, Bastami M, Ghaedi H, Moghadam F, Mirfakhraie R, Omrani M D. MAP3K1 May be a Promising Susceptibility Gene for Type 2 Diabetes Mellitus in an Iranian Population. Int J Mol Cell Med. 2016; 5 (3) :134-140
URL: http://ijmcmed.org/article-1-529-fa.html
MAP3K1 May be a Promising Susceptibility Gene for Type 2 Diabetes Mellitus in an Iranian Population. مجله بین المللی سلولی و مولکولی. 1395; 5 (3) :134-140

URL: http://ijmcmed.org/article-1-529-fa.html

دوره 5، شماره 3 - ( 4-1395 ) برگشت به فهرست نسخه ها
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
Persian site map - English site map - Created in 0.047 seconds with 803 queries by yektaweb 3506