:: Volume 5, Number 3 (Int J Mol Cell Med 2016) ::
Int J Mol Cell Med 2016, 5(3): 160-166 Back to browse issues page
Utility of Specific IgE to Ara h 2 in Italian Allergic and Tolerant Children Sensitized to Peanut
Pasquale Comberiati1, Laura Colavita *2, Federica Minniti1, Paiola Giulia1, Carlo Capristo3, Cristoforo Incorvaia4, Giampietro Peroni Diego5
1- Department of Scienze Chirurgiche, Odontostomatologiche e Materno-infantili, section of Paediatrics, University of Verona, Italy., Department of Scienze Chirurgiche, Odontostomatologiche e Materno-infantili, section of Paediatrics, University of Verona, Italy.
2- Department of Paediatrics, Unit of Genetics and Pediatric Immunology, University Hospital of Messina, Italy., Department of Paediatrics, Unit of Genetics and Pediatric Immunology, University Hospital of Messina, Italy. , lauracol85@gmail.com
3- Department of Paediatrics, Faculty of Medicine, Second University of Naples, Naples, Italy., Department of Paediatrics, Faculty of Medicine, Second University of Naples, Naples, Italy.
4- Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, Italy., Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, Italy.
5- Department of Clinical and Experimental Medicine, section of Paediatrics, University of Pisa, Italy., Department of Clinical and Experimental Medicine, section of Paediatrics, University of Pisa, Italy.
Abstract:   (1589 Views)

Emerging data suggest that measurement of serum IgE to peanut components can be clinically helpful and more accurate than IgE to whole peanut to predict peanut allergy. Not all studies have used prospective samples, multiple components and oral challenges. Currently, there are no data on this topic involving Italian children. 32 patients (23 males; median age 9 years) with reported history for peanut allergy and evidence of peanut sensitization (skin prick test to peanut extract ≥ 3mm) have been analyzed for serum IgE to whole peanut and recombinant allergen components Ara h 1, 2, 3, 8, and 9 with Immuno CAP and completed an open oral food challenge with peanut. 12 (37.5%) children had a positive challenge to peanut and were considered allergic. No differences were seen between the median values of IgE to peanut, Ara h 1, 3, 8 and 9 in allergic and tolerant children to peanut challenge. Noteworthy, 5 of 20 tolerant children had IgE to peanut> 15 kUA/l which is commonly considered a predictive value of peanut allergy. Conversely, a significant difference was seen when comparing the median value of IgE to Ara h 2 in the two groups: 0.75 kUA/l (IQR: 0.22-4.34 kUA/l) in allergic children versus 0.1 kUA/l (IQR: 0.1-0.12 kUA/l) in tolerant ones (P< 0.001). IgE levels to Ara h 2 are significantly higher in children that react to oral peanut challenge. Our findings in Italian children have been in line with recent reports in various populations of Northern Europe, the US and Australia and add confirmatory evidence that analysis of IgE to Ara h 2 could reduce the need for peanut challenge in suspected allergic patients.

Keywords: Allergy, Ara h 2, peanut, specific Ig E
Full-Text [PDF 139 kb]   (744 Downloads)    
Type of Study: Original Article | Subject: Biomarkers (diagnosis & treatment)
Received: 2016/05/1 | Accepted: 2016/07/9 | Published: 2016/08/9



DOI: 10.22088/acadpub.BUMS.5.3.160


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