Orosomucoid-1 Expression in Ameloblastoma Variants
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Alejandro García-Muñoz1 , Ronell Bologna-Molina2 , Mario A. Rodríguez3 , Rodrigo Liceaga-Reyes4 , Jose Eduardo Farfán-Morales5 , Saray Aranda-Romo6 , Nelly Molina-Frechero7 , Rogelio González-González 8 |
1- Laboratorio de Investigación en Odontología, ALMARAZ/UBIMED, FES Iztacala, UNAM. State of Mexico, Mexico. 2- Molecular Pathology, Universidad de la República (UDELAR), Montevideo, Uruguay. 3- Department of Infectomics and Molecular Pathogenesis, CINVESTAV-IPN, México, D.F, México. 4- Maxillofacial Surgery Department. Hospital Juárez de México, México D.F, México. 5- Instituto Nacional de Pediatría, México D.F, México. 6- Biochemistry, Microbiology and Pathology Laboratory, Faculty of Stomatology, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico. 7- Health Care Department, Universidad Autónoma Metropolitana, Xochimilco, UAM, México City, Mexico. 8- Department Research, School of Dentistry, Universidad Juárez del Estado de Durango, México. , rogegg@hotmail.com |
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Abstract: (10484 Views) |
Odontogenic tumors constitute a group of heterogeneous lesions of benign and malignant neoplasms with variable aggressiveness. Ameloblastomas are a group of benign but locally invasive neoplasms that occur in the jaws and are derived from epithelial elements of the tooth-forming apparatus. We previously described orosomucoid-1 protein expression in odontogenic myxomas. However, whether orosomucoid-1 is expressed in other odontogenic tumors remains unknown. Since orosomucoid-1 belongs to a group of acute-phase proteins and has many functions in health and disease, we identified and analyzed orosomucoid-1 expression in ameloblastoma variants and ameloblastic carcinoma using western blot and immunohistochemical techniques. Thirty cases of ameloblastoma were analyzed for orsomucoid-1; five specimens were fresh for western blot study (four benign ameloblastomas and one ameloblastic carcinoma), and 25 cases of benign ameloblastoma for immunohistochemical assays. Orosomucoid-1 was widely expressed in each tumor variant analyzed in this study, and differential orosomucoid-1 expression was observed between benign and malignant tumor. Orosomucoid-1 may play an important role in the behavior of ameloblastomas and influence the biology and development of the variants of this tumor. |
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Keywords: Orosomucoid-1, ameloblastoma, ameloblastic carcinoma, odontogenic tumors |
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Full-Text [PDF 505 kb]
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Type of Study: Original Article |
Subject:
Histopathology Received: 2015/11/24 | Accepted: 2016/01/9 | Published: 2016/02/3
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