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Cancer Stem Cell Markers CD44, CD133 in Primary Gastric Adenocarcinoma
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Anahita Nosrati1   , Farshad Naghshvar 2, Somaieh Khanari1 |
1- Department of Pathology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
2- Department of Pathology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran. , Farshad.Naghshvar@yahoo.com |
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Abstract: (9622 Views) |
| Cancer stem cells (CSCs) are unique subpopulations that have the capacity to drive malignant progression with renewal abilities. Recently the role of some of CSCs in gastric adenocarcinoma has been studied. This study was performed in order to evaluate CD44 and CD133 expressions by immunohistochemistry in 95 primary gastric adenocarcinoma and their relation to clinical and pathological parameters of these tumors. There was a significant correlation between CD44 expression and cancer subtype (intestinal), tumor size (4-8 cm), depth of invasion, no lymphatic/vascular invasion and moderate differentiation. There was a significant correlation between CD133 expression and patient's age (> 65 years), cancer subtype (intestinal), tumor size (4-8 cm), depth of invasion and moderate differentiation. CSC markers like CD 44 and CD133 had high expression in primary gastric adenocarcinoma and had some relations to clinical and pathological parameters of tumors. |
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| Keywords: Primary gastric adenocarcinoma, cancer stem cell, CD44, CD133, immunohistochemistry |
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Full-Text [PDF 260 kb]
(3104 Downloads)
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Type of Study: Original Article |
Subject:
Stem Cell
Received: 2014/07/3 | Accepted: 2014/09/20 | Published: 2014/10/12
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