:: Volume 10, Issue 4 (Int J Mol Cell Med (In Press) 2021) ::
Int J Mol Cell Med 2021, 10(4): 0-0 Back to browse issues page
Roles of Renin-Angiotensin System in the Regulation of Prostate Cancer Bone Metastasis: A Critical Review
Manh Tien Tran
Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan. , trantienmanh1508@gmail.com
Abstract:   (1697 Views)
Mestastatic prostate cancer cells (MPCCs) frequently metastasize to bone, which is a “favorite soil” for colonization and proliferation of MPCCs. Prostate cancer bone mestastasis is tightly associated with tumor-induced bone lesions, most commonly caused from the etiological imbalance between osteoblastic bone formation and osteoclastic bone resorption, and from the anti-tumor immune response. Therefore, the understanding of prostate cancer biology and prostate cancer bone metastasis has led to the establishment of drug development programs for treatment of the patients with bone metastasis. The renin-angiotensin system (RAS) controls systemic body fluid circulation; nonetheless, the existence of a local RAS in tumors has been reported. Importantly, the local RAS has recently emerged as a potential regulator of tumorigenesis and cancer metastasis. This review summarizes and dissects the critical roles of the local RAS in promoting the progression of metastatic prostate cancer, and development and progression of PCa bone metastasis, thereby providing multiple solutions for the potential therapeutic intervention.  
Keywords: RAS, metastatic prostate cancer, prostate cancer bone metastasis, bone microenvironment
Type of Study: Review | Subject: Cancer
Received: 2021/08/11 | Accepted: 2021/12/7 | Published: 2022/01/3

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Volume 10, Issue 4 (Int J Mol Cell Med (In Press) 2021) Back to browse issues page