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Altered mRNA Expression of Fucosyltransferases and Fucosidase Predicts Prognosis in Human Oral Carcinoma
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Kruti Mehta1    , Kinjal Patel1 , Shashank Pandya2 , Prabhudas Patel 3 |
1- Molecular Oncology Laboratory, Cancer Biology Department, The Gujarat Cancer & Research Institute, Asarwa, Ahmedabad, Gujarat, India.
2- Surgical Oncology Department, The Gujarat Cancer & Research Institute, Asarwa, Ahmedabad, Gujarat, India.
3- Molecular Oncology Laboratory, Cancer Biology Department, The Gujarat Cancer & Research Institute, Asarwa, Ahmedabad, Gujarat, India. , prabhudas_p@hotmail.com |
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Abstract: (3581 Views) |
| Aberrant protein glycosylation is known to be associated with the development of various cancers. Although fucosylation is essential for normal biological functions, alterations in fucosylation are strongly implicated in cancer and increasing metastatic potential. Altered fucosyltarnsferases (FUTs) and fucosidases are found to be involved in many types of malignancies. In this study, we examined the mRNA expressions of fucosidase (FUCA1) and FUTs (FUTs (FUT3, FUT4, FUT5, FUT6, FUT8) in human oral cancer tissues. All FUTs and FUCA1 were significantly (P ≤ 0.05) down-regulated in malignant tissues in comparison with their adjacent normal tissues. The relationship between the clinicopathological parameters and the expression of FUTs and FUCA1 revealed that higher mRNA levels of FUT4, FUT5, and FUT8 and lower levels of FUT3 were associated with progression of disease and lymph node metastasis in oral carcinoma indicating their role in oral cancer progression. Collectively, results suggest that elevated mRNA levels of FUT4, FUT5 and FUT8 may be used as worst prognostic indicators for oral carcinoma. |
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| Keywords: Oral cancer, hallmarks of cancer, glycosylation, fucosylation, fucosyltransferases, fucosidase |
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Full-Text [PDF 470 kb]
(1186 Downloads)
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Type of Study: Original Article |
Subject:
Cancer
Received: 2020/11/18 | Accepted: 2021/05/28 | Published: 2021/05/30
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