:: Volume 8 - Suppl 1_Int J Mol Cell Med ::
Int J Mol Cell Med 2019, 8 - Suppl 1_Int J Mol Cell Med: 30-40 Back to browse issues page
Metabolomics Analysis of Mesenchymal Stem Cells
Parisa Goodarzi1, Sepideh Alavi-Moghadam2, Moloud Payab3, Bagher Larijani4, Fakher Rahim5, Kambiz Gilany6, Nikoo Bana7, Akram Tayanloo-Beik2, Najmeh Foroughi Heravani2, Mahdieh Hadavandkhani2, Babak Arjmand 8
1- Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
2- Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
3- Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
4- Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical sciences, Tehran, Iran.
5- Health Research Institute, Thalassemia and Hemoglobinopathies Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
6- Integrative Oncology Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran; Department of Biomedical Sciences, University of Antwerp, Belgium.
7- Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular- Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
8- Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. , barjmand@sina.tums.ac.ir
Abstract:   (2292 Views)
Various mesenchymal stem cells as easily accessible and multipotent cells can share different essential signaling pathways related to their stemness ability. Understanding the mechanism of stemness ability can be useful for controlling the stem cells for regenerative medicine targets. In this context, OMICs studies can analyze the mechanism of different stem cells properties or stemness ability via a broad range of current high-throughput techniques. This field is fundamentally directed toward the analysis of whole genome (genomics), mRNAs (transcriptomics), proteins (proteomics) and metabolites (metabolomics) in biological samples. According to several studies, metabolomics is more effective than other OMICs ّfor various systems biology concerns. Metabolomics can elucidate the biological mechanisms of various mesenchymal stem cells function by measuring their metabolites such as their secretome components. Analyzing the metabolic alteration of mesenchymal stem cells can be useful to promote their regenerative medicine application.
Keywords: Mesenchymal stem cells, metabolic pathways, metabolomics, systems biology
Full-Text [PDF 403 kb]   (191 Downloads)    
Type of Study: Review | Subject: Stem Cell
Received: 2019/03/13 | Accepted: 2019/05/20 | Published: 2019/07/5



XML     Print



Volume 8 - Suppl 1_Int J Mol Cell Med Back to browse issues page