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:: Volume 6, Number 1 (Int J Mol Cell Med 2017) ::
Int J Mol Cell Med 2017, 6(1): 31-37 Back to browse issues page
Analysis of Two CDKN2B-AS Polymorphisms in Relation to Coronary Artery Disease Patients in North of Iran
Maryam Mafi Golchin1, Sayyed Mohammad Hossein Ghaderian *2, Haleh Akhavan-Niaki1, Rozita Jalalian3, Laleh Hedari4, Ali Reza Salami5
1- Department of Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran., Department of Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
2- Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , sghaderian@yahoo.co.uk
3- Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran., Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
4- Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
5- Department of Biotechnology, University of Tehran, Tehran, Iran., Department of Biotechnology, University of Tehran, Tehran, Iran.
Abstract:   (1028 Views)

Coronary artery disease (CAD) including myocardial infarction (MI) as its complication, is one of the most common heart diseases worldwide and also in Iran, with extremely elevated mortality. CAD is a multifactorial disorder. Twin and family studies at different loci have demonstrated that genetic factors have an important role in the progression of CAD. Many studies have reported a significant association of CDKN2B-AS, also known as ANRIL which is located within the p15, p16, p14 gene cluster at 9p21 locus,  with cardiovascular diseases as well as many other diseases like diabetes and cancers. This study investigated two polymorphisms rs10757274 and rs1333042 of CDKN2B-AS gene at 9p21 locus. 205 subjects, comprising 102 controls and 103 CAD patients were genotyped by TaqMan probe real time PCR technique and haplotypes were examined. This study confirmed the association of rs10757274 variants with CAD in Iranian patients (P= 0.003) but genotype and allele distributions of CAD and control groups showed no significant association for the rs1333042. However, frequency of the [G;G] haplotype of these two SNPs was significantly higher in CAD group (P= 0.0002, Odds Ratio = 3.1, 95% CI = 1.7-5.7). Our finding suggests that [G; G]  haplotype of rs10757274 and rs1333042 may be considered  as a genetic risk factor for susceptibility to CAD in Iranian patients.

Keywords: Single nucleotide polymorphism, risk factor, coronary artery disease, CDKN2B-AS, Iranian
Full-Text [PDF 368 kb]   (354 Downloads)    
Type of Study: Original Article | Subject: Genetics & Disease
Received: 2016/05/2 | Accepted: 2016/08/21 | Published: 2016/12/2
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DOI: 10.22088/acadpub.BUMS.6.1.31


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Mafi Golchin M, Ghaderian S M H, Akhavan-Niaki H, Jalalian R, Hedari L, Salami A R. Analysis of Two CDKN2B-AS Polymorphisms in Relation to Coronary Artery Disease Patients in North of Iran. Int J Mol Cell Med. 2017; 6 (1) :31-37
URL: http://ijmcmed.org/article-1-514-en.html
Volume 6, Number 1 (Int J Mol Cell Med 2017) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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