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:: Volume 5, Issue 1 (Int J Mol Cell Med 2016) ::
Int J Mol Cell Med 2016, 5(1): 8-18 Back to browse issues page
Zinc Finger 259 Gene Polymorphism rs964184 is Associated with Serum Triglyceride Levels and Metabolic Syndrome
Seyed Reza Mirhafez1, Amir Avan2, Alireza Pasdar3, Sara Khatamianfar2, Leila Hosseinzadeh2, Shiva Ganjali2, Ali Movahedi1, Maryam Pirhoushiaran4, Valentina Gómez Mellado4, Domenico Rosace5, Anne Van Krieken6, Mahdi Nohtani2, Gordon A. Ferns7, Majid Ghayour-Mobarhan 2
1- Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran.
2- Department of Modern Science and Technologies; and Biochemistry of Nutrition Research Center; School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3- Division of Applied Medicine, Medical School, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK.
4- VU University Medical Center, Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
5- University of Bologna, Bologna, Italy.
6- Peter MacCallum Centre, St Andrew's Place, Melbourne, Australia.
7- Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK.
Abstract:   (5829 Views)

Metabolic syndrome (MetS) is characterized by a cluster of cardiovascular risk factors that include: abdominal obesity, dyslipidaemia, hypertension, insulin resistance and impaired glucose tolerance. Recent genome wide association studies have identified several susceptibility regions involved in lipid metabolism that are also associated with MetS. We have explored the association of 9 genetic polymorphisms involved in lipid metabolism and hypertension, including: MTHFR C677T, SELE L554F, FGB - 455G>A, GNB3 C825T, ZNF259 C>G, PSRC-1 A>G, CETP I405V, LPL S447X and LPA C>T in 97 subjects with mets and 96 individuals without MetS who were recruited randomly from Mashhad stroke and heart atherosclerotic disorder (MASHAD) study using a stratified cluster random sampling technique. Anthropometric parameters and biochemical measurements were determined in all the subjects. Genotyping was carried out followed by univariate and multivariate analyses. The subjects with MetS had a higher triglyceride and lower HDL- C. CG+ GG genotypes of ZNF259 polymorphism (rs964184 C>G) and TT+CT genotypes of MTHFR C677T (rs1801133) were associated with MetS, and individuals carrying the G allele for ZNF259 or the T allele for MTHFR polymorphisms were associated with MetS (e.g, odds ratio (OR) for CG+GG genotypes vs. CC wild type: 2.52, CI=1.33-4.77; P=0.005). However, after multiple comparison adsustments, this relationship remained significant only for CG+ GG genotypes of ZNF259 polymorphism. Moreover, the ZNF259 CG+ GG genotypes were associated with increased serum concentrations of triglycerides and LDL-C, compared to the wild type. These data support the necessity of further studies in larger multicenter settings.

Keywords: Metabolic syndrome, gene polymorphisms, lipid pathway
Full-Text [PDF 288 kb]   (1647 Downloads)    
Type of Study: Original Article | Subject: Genetics & Disease
Received: 2015/12/7 | Accepted: 2016/02/20 | Published: 2016/03/8
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Mirhafez S R, Avan A, Pasdar A, Khatamianfar S, Hosseinzadeh L, Ganjali S, et al . Zinc Finger 259 Gene Polymorphism rs964184 is Associated with Serum Triglyceride Levels and Metabolic Syndrome. Int J Mol Cell Med. 2016; 5 (1) :8-18
URL: http://ijmcmed.org/article-1-428-en.html


Volume 5, Issue 1 (Int J Mol Cell Med 2016) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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