[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
Submission ::
Ethics::
Registration::
Contact us::
Site Facilities::
::
Impact Factor
Impact Factor 2022: 1.9
5-Year Impact Factor: 2.2
Cite Score 2022: 3.9
SJR 2022: 0.447
SNIP 2022: 0.538

 
..
Publication Fee
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 2, Issue 4 (Int J Mol Cell Med 2013) ::
Int J Mol Cell Med 2013, 2(4): 199-203 Back to browse issues page
HER-2/neu Marker Examination using Immunohistochemical Method in Patients Suffering from Gastric Adenocarcinoma
Kourosh Movagharnejad1 , Majid Sharbatdaran 2, Shahryar Shefaee3 , Mehrdad Kashifard4 , Sadegh Sedaghat5
1- Department of pathology, Rohani hospital, Babol University of Medical Sciences, Babol, Iran.
2- Department of pathology, Rohani hospital, Babol University of Medical Sciences, Babol, Iran. , sharbatdaran@yahoo.com
3- Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran.
4- Department of Internal medicine , Rohani hospital, Babol University of Medical Sciences, Babol, Iran.
5- Department of Hematology and Oncology, Rohani hospital, Babol University of Medical Sciences, Babol, Iran.
Abstract:   (14744 Views)
Gastric adenocarcinoma is the second leading cause of death due to cancer in the world and in advanced stages the prognosis is poor with current therapies. Over-expression of HER-2/neu has been seen in several cancers such as gastric cancer and its expression is associated with poor prognosis. The aim of this study is to evaluate the over-expression of HER-2/neu in gastric biopsy samples of patients with gastric carcinoma diagnosis and to evaluate its probable relationship with clinical and pathological findings. The over-expression of HER-2/neu was examined retrospectively by immunohistochemistry method in 60 paraffin embedded samples collected in Babol, Iran, between 2010 and 2011. The over-expression of HER-2/neu has been observed in 6 patients (10%) and this over-expression was greater in the intestinal type of gastric adenocarcinoma than the diffuse type (12% vs. 6%) however, no statistically significant correlation between HER-2/neu expression and subtype, degree of differentiation, tumor type and age was observed. This over-expression was greater in differentiated types than undifferentiated types (18% vs. 5%).
Keywords: HER-2/neu, gastric cancer, immunohistochemistry
Full-Text [PDF 147 kb]   (2877 Downloads)    
Type of Study: Original Article | Subject: Histopathology
Received: 2013/07/10 | Accepted: 2013/11/24 | Published: 2013/11/24
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Movagharnejad K, Sharbatdaran M, Shefaee S, Kashifard M, Sedaghat S. HER-2/neu Marker Examination using Immunohistochemical Method in Patients Suffering from Gastric Adenocarcinoma. Int J Mol Cell Med 2013; 2 (4) :199-203
URL: http://ijmcmed.org/article-1-94-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 2, Issue 4 (Int J Mol Cell Med 2013) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
Persian site map - English site map - Created in 0.06 seconds with 38 queries by YEKTAWEB 4645