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:: Volume 11, Issue 2 (Int J Mol Cell Med 2022) ::
Int J Mol Cell Med 2022, 11(2): 137-149 Back to browse issues page
hsa-miR-508-5p as a New Potential Player in Intervertebral Disc Degeneration
Akram Gholipour1 , Mahshid Malakootian1 , Maziar Oveisee 2
1- Cardiogenetic Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
2- School of Medicine, Bam University of Medical Sciences, Bam, Kerman, Iran. , Maziar.oveisee@gmail.com
Abstract:   (1482 Views)
Intervertebral disc degeneration (IDD) is widely known as the principal cause of low back pain, diminishing patients’ quality of life and imposing a huge economic burden on healthcare systems worldwide. However, the underlying mechanisms of IDD remain to be determined. This study aimed to scrutinize data sets via bioinformatics to identify microRNAs (miRNAs)/genes and pathways associated with IDD. The array profiling of patients with IDD and individuals without IDD was acquired from the Gene Expression Omnibus (GEO) database (viz., GSE19943, GSE63492, and GSE34095). The expression profiles of miRNAs and genes with differential patterns were analyzed using GEO2R. The target genes of the chosen miRNA were then examined, and in silico functional analyses were performed on the signaling pathways and biological processes of the differentially expressed genes. Three human miRNAs were up and downregulated in IDD patients in the examined data sets. Among them, hsa-miR-508-5p had a significant differential expression in the IDD group, and SEC11A, IPO5, FN1, and MRPS10, as the targets of hsa-miR-508-5p, were upregulated in the IDD group. Furthermore, extracellular matrix-receptor interactions, focal adhesion, and actin cytoskeleton regulation were important pathways involved in IDD. Our analysis identified hsa-miR-508-5p as a novel miRNA involved in IDD pathogenies. Our findings not only further confirm the significant role of miRNAs in IDD pathogenesis but also extend the spectrum of the miRNAs and genes involved in IDD. Still, further experimental investigations are needed to confirm our findings.
Keywords: Intervertebral disc degeneration, hsa-miR-508-5p, Noncoding RNA regulators, Low back pain
Full-Text [PDF 694 kb]   (1219 Downloads)    
Type of Study: Original Article | Subject: Other
Received: 2022/08/12 | Accepted: 2022/11/28 | Published: 2022/11/28
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Gholipour A, Malakootian M, Oveisee M. hsa-miR-508-5p as a New Potential Player in Intervertebral Disc Degeneration. Int J Mol Cell Med 2022; 11 (2) :137-149
URL: http://ijmcmed.org/article-1-1986-en.html

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Volume 11, Issue 2 (Int J Mol Cell Med 2022) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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