[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 1, Issue 1 (Int J Mol Cell Med 2012) ::
Int J Mol Cell Med 2012, 1(1): 44-49 Back to browse issues page
Effects of Teucrium Polium Aerial Parts extract on oral glucose tolerance tests and pancreas histopathology in Streptozocin-induced diabetic rats
Mohsen Tatar 1, Durdi Qujeq *2, Farideh Feizi 3, Hadi Parsian 4, Alieh Sohan Faraji 3, Sohrab Halalkhor 1, Roya Abassi 1, Zeinab Abedian 4, Roughayeh Pourbagher 4, Seyed Mohsen Aghajanpour Mir 4, Hamed Mir 1, Nayer Seyfizadeh 1
1- Department of Biochemistry & Biophysics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
2- Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran. , dqujeq@hotmail.com
3- Department of Anatomical Sciences, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
4- Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran.
Abstract:   (12584 Views)
Teucrium polium can reduce serum glucose. There are few reports in the literature related to this subject and the resolution of this mechanism requires further experiments. The aim of the present study was to evaluate the effects of Teucrium polium aerial parts extracts on oral glucose tolerance tests and pancreas histology in streptozocin-induced diabetic rats. In order to prepare the aqueous concentrate, aerial parts extract was dissolved in distilled water and was boiled for 30 minutes. For the preparation of ethanolic solution, powder was dissolved in ethanol and mixed by a shaker. Diabetic rats were induced with single IP injection of streptozotocin (STZ) at a dose of 50 mg/kg body weight dissolved in normal saline just before use to the 16 hr fast rats. Both groups, diabetic and normal were sacrificed by ether anesthesia. The tissue samples were formalin fixed and paraffin embedded for microscopic examination in accordance with routine laboratory procedures. Blood was collected from the tail vein of the rats. Serum glucose levels were then measured by commercial kits by using a glucose oxidized method. There were no biochemical abnormalities or histological changes in the pancreas of control rats. Post treatment of Teucrium polium aerial parts extract reduced the severity of streptozotocin diabetic pancreases. Our histopathological investigation along with the biochemical evaluations showed a significant effect on histological changes in the pancreas of induced diabetic rats upon Teucrium polium aerial parts extract treatment (P<0.05).
Keywords: Teucrium polium, oral glucose tolerance tests, pancreas histology, streptozocin, diabetic rats
Full-Text [PDF 741 kb]   (3812 Downloads)    
Type of Study: Original Article | Subject: Clinical Biochemistry
Received: 2012/02/22 | Accepted: 2013/09/14 | Published: 2013/09/14
Send email to the article author

Add your comments about this article
Your username or Email:

Write the security code in the box >



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Tatar M, Qujeq D, Feizi F, Parsian H, Sohan Faraji A, Halalkhor S, et al . Effects of Teucrium Polium Aerial Parts extract on oral glucose tolerance tests and pancreas histopathology in Streptozocin-induced diabetic rats . Int J Mol Cell Med. 2012; 1 (1) :44-49
URL: http://ijmcmed.org/article-1-37-en.html
Volume 1, Issue 1 (Int J Mol Cell Med 2012) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
Persian site map - English site map - Created in 0.049 seconds with 817 queries by yektaweb 3509