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The Expression Pattern and Clinicopathological Importance of Hsa_circ_000425 in Colorectal Cancer
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Davood Mohammadi1    , Ali Bastani2 , Yazdan Zafari3 , Sohrab Esmeilazadeh4 , Nafiseh Rastgoo4 , Mohammad Bargahi4 , Sahar Moghbelinejad 5 |
1- Department of Surgery, School of medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
2- Department of Internal Medicine, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
3- Department of Hematology and Medical Oncology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
4- School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
5- Research Institute for Prevention of Non-Communicable Diseases, Cellular and Molecular Research Centre, Qazvin University of Medical Sciences, Qazvin, Iran. , smoghbelinejad@qums.ac.ir |
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Abstract: (3178 Views) |
| Although colorectal cancer (CRC) is one of the most common cancers, the exact molecular mechanism of this cancer is not yet known. Circular RNAs (circRNAs), a class of non-coding RNAs, are newly identified and their role in the pathogenesis of various cancers has been shown. In this research, we studied the expression pattern and clinical importance of hsa_circ_000425 in CRC patients. After evaluation of hsa_circ_000425 expression rate in 4 CRC cell lines and 100 paired CRC tissues, the potential correlation between hsa_circ_000425 expression rate and clinicopathological parameters of CRC patients was analyzed. Additionally, receiver operating characteristic (ROC) curve was drawn to study the diagnostic value of hsa_circ_000425. A significant down regulation of hsa_circ_000425 was observed in both CRC tissues and cell lines. In addition, this downregulation was significantly associated with differentiation and lymphatic metastasis. The area under the ROC curve of hsa_circ_000425 was 0.839 (P < 0.001). hsa_circ_000425 may have a role in the pathogenesis of CRC and might act as a potential biomarker for the diagnosis and treatment of CRC; although further molecular studies must be performed in this regard. |
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| Keywords: Circular RNA, hsa_circ_000425, colorectal neoplasm |
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Full-Text [PDF 400 kb]
(1295 Downloads)
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Type of Study: Original Article |
Subject:
Cancer
Received: 2020/09/19 | Accepted: 2021/01/2 | Published: 2020/11/30
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