en Other Other Review Review <p style="text-align: justify;"><span style="font-family:Tahoma;"><span style="font-size:11pt"><span style="line-height:107%">The process of osseointegration for dental implants is complex and can be influenced by localized inflammation. The NF-&kappa;B signaling system plays a crucial role in regulating inflammatory responses. This article examines the role of microRNAs (miRNAs) in regulating the NF-&kappa;B pathway in inflammatory conditions associated with dental implants, including periodontitis, alveolar bone abnormalities, and estrogen deficiency models. A review of prior research demonstrates that miRNAs, specifically miR-146a, miR-21a-5p, miR-182, and miR-100-5p, modulate NF-&kappa;B activation and maintain the balance between osteogenesis and osteoclastogenesis by targeting molecules such as FoxO1, TLR4, and PDCD4. These interactions lead to a reduction in reactive oxygen species, inhibition of pro-inflammatory cytokines (including IL-1&beta; and TNF-&alpha;), and an elevation in osteogenic markers (such as Runx2 and ALP). The findings indicate that the miRNA-NF-&kappa;B axes can lead to peri-implantitis and implant failure. On the other hand, miRNA-based therapeutics, such as agomirs and antagomirs, might assist improve osseointegration outcomes. This study highlights the importance of miRNAs in modulating NF-&kappa;B inflammation for the effectiveness of dental implants and provides suggestions for further research.</span></span></span></p> MicroRNAs, the NF-B pathway, inflammation, dental implants, osseointegration, bone regeneration, peri-implantitis, periodontitis 0 0 http://ijmcmed.org/browse.php?a_code=A-10-8750-1&slc_lang=en&sid=1 Ghazal Soleimani ghazal.soleimani73@gmail.com 100319475328460036873 0009-0006-1583-2282 No Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Pouria Farahani 100319475328460036874 0009-0003-5133-0720 No Faculty of Dentistry, Dental Surgery Shahid beheshti University of Medical science, ,Tehran, Iran. Ailar Yousefbeigi ailar.yousefbeigi@ucla.edu 100319475328460036875 0009-0002-6955-9286 No DDS, Graduate Student, School of Dentistry, University of California, Los Angeles (UCLA), Los Angeles, California, United States Diyako Farajpur diyakofarajpur@gmail.com 100319475328460036876 100319475328460036876 No Faculty of Dentistry, kermanshah university of medical sciences, Kermanshah, Iran. Paria Amooyan 75.parya@gmail.com 100319475328460036877 100319475328460036877 No Department of Endodontics, Faculty of Dentistry, Shahed University, Tehran, Iran. Asieh Mozaffari asiehmozaffari@yahoo.com 100319475328460036878 100319475328460036878 No Department of Periodontics, Faculty of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran. mina aghabeigi mina.aghabeigi@gmail.com 100319475328460036872 0009-0007-2031-9325 Yes Department of Periodontology, School of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahwaz, Iran